A clue to the GI problems that plague many kids with autism?

New research conducted in the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health, reports that children with autism and gastrointestinal disturbances have high levels of a bacterium called Sutterella in their intestines.

Study findings are published online in the journal mBio.

The investigators found that over half of the children diagnosed with autism and gastrointestinal disturbances had Sutterella in intestinal biopsy tissue, while Sutterella was absent in biopsies from typically developing children with gastrointestinal disturbances. Not only was Sutterella present in the intestines of children with autism, but relative to most genera of bacteria, Sutterella was present at remarkably high levels. Sutterella species have been isolated from human infections previous to this study, but it remains unclear whether this bacterium is a human pathogen.

“These findings shine a light on a bacterium about which we know very little, in a disorder for which we have few answers,” says Brent Williams, PhD, the lead author on the study. “There is much work to be done toward understanding the role Sutterella plays in autism, the microbiota, infections, and inflammation.”

The researchers examined intestinal biopsies from 32 patients, 23 diagnosed with autism and 9 typically developing children. While previous studies investigating a link between the microbiota and autism have utilized stool samples, the study was unique in investigating bacteria adherent to the intestinal wall, which may be different than what is shed in the stool. Furthermore, the researchers designed and applied novel Sutterella-specific molecular assays to enable detection, quantitation, and phylogenetic analysis of Sutterella species in biological and environmental samples.

Many children with autism have gastrointestinal problems that can complicate clinical management and contribute to behavioral disturbances. However, the underlying reason that autism is associated with gastrointestinal disturbances is unknown.

“Although caution in interpretation is indicated because this is a small cohort, microbiome research may provide new insights into gastrointestinal disturbances that develop in children with autism,” notes Mady Hornig, MD, Mailman School associate professor and director of Translational Research at the CII.

About Columbia University's Mailman School of Public Health

Founded in 1922 as one of the first three public health academies in the nation, Columbia University's Mailman School of Public Health pursues an agenda of research, education, and service to address the critical and complex public health issues affecting New Yorkers, the nation and the world. The Mailman School is the third largest recipient of NIH grants among schools of public health. Its over 300 multi-disciplinary faculty members work in more than 100 countries around the world, addressing such issues as preventing infectious and chronic diseases, environmental health, maternal and child health, health policy, climate change & health, and public health preparedness. It is a leader in public health education with over 1,000 graduate students from more than 40 nations pursuing a variety of master's and doctoral degree programs. The Mailman School is also home to numerous world-renowned research centers including the International Center for AIDS Care and Treatment Programs (ICAP), the National Center for Disaster Preparedness, and the Center for Infection and Immunity. For more information, please visit www.mailman.columbia.edu

Media Contact

Stephanie Berger EurekAlert!

Weitere Informationen:

http://www.columbia.edu

Alle Nachrichten aus der Kategorie: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

Surplus sugar helps whiteflies detoxify plant defenses

This pest insect uses sugar from its food to prevent the activation of the mustard oil bomb in cruciferous plants. Worldwide dreaded crop pest of hundreds of plant species Whiteflies…

Copycat plant booster improves on nature

A molecule that can mimic the function of zaxinone, a natural growth-promoting plant metabolite, has been designed and fabricated by an international team led by KAUST and the University of…

Discovery of large family of two-dimensional ferroelectric metals

It is usually believed that ferroelectricity can appear in insulating or semiconducting materials rather than in metals, because conducting electrons of metals always screen out the internal static electric field…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close