Protein design – A construction kit full of opportunities

Dr. Birte Höcker Jörg Abendroth / Max Planck Institute for Developmental Biology

Höcker, a biochemist, studies the evolution of proteins and uses her knowledge to construct new ones. She could already show that the diversity of proteins formed from smaller fragments, which led her to a new scientific approach: Use these parts and recombine them according to a construction kit. Fittingly, her ERC project application is called “Protein Lego”.

“With this project application we follow a completely new approach to protein design”, says Birte Höcker. “We identify stable fragments of well-known protein structures, recombine them, and so we see new complex and functional proteins coming to life.”

The scientist is fascinated by the composition of these essential proteins. “In the first place, the activity of proteins makes life possible”, states Höcker. “And I am particularly interested in all these little details of their structures – how they differ from each other and why they fold the way they do.”

The deeper understanding of protein structures can help to build tailor-made proteins for use in biotechnology, medicine and synthetic biology. Protein design has a broad application range, for example creating new enzymes for manufacturing fine chemicals or degrading toxic material, for new protein based drugs or even as biosensors as tools in basic research.

“Currently we focus primarily on the basics of this technology”, Höcker underlines. Together with her research group she wants to lay the foundation, so that tailor-made proteins for specific applications can be constructed in the near future.

The ERC Grants are the most coveted awards in the European research landscape. Each year the European Research Council supports upcoming scientists of any nationality with Consolidator Grants. The awardees have to carry out excellent research projects and should have finished their doctoral degree at least seven years ago.

About Birte Höcker:
Dr. Birte Höcker finished her doctoral degree in biochemistry in 2003 at the University of Cologne, before she worked as a postdoc at the Duke University Medical Center in the USA. Since 2006, she is an Independent Research Group Leader at the Max Planck Institute for Developmental Biology in Tübingen, Germany.

About us:
The Max Planck Institute for Developmental Biology conducts basic research in the fields of biochemistry, genetics and evolutionary biology. It employs about 360 people and is located at the Max Planck Campus in Tübingen. The Max Planck Institute for Developmental Biology is one of 83 research institutes that the Max Planck Society for the Advancement of Science maintains in Germany.

http://www.mpg.de/9042487/erc-consolidator-grants-2014
http://erc.europa.eu/sites/default/files/press_release/files/press_release_cog20…

Media Contact

Nadja Winter Max-Planck-Institut für Entwicklungsbiologie

Alle Nachrichten aus der Kategorie: Awards Funding

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

Simplified method to modify disease signaling with light

Most diseases are caused by aberrant cell signaling processes and basic research in cell signaling is needed to identify targets for future therapeutic approaches, especially in cases where no cures…

Highly selective membranes

Researchers discover how water can affect its own filtration. Membranes with microscopic pores are useful for water filtration. The effect of pore size on water filtration is well-understood, as is…

Interactions within larger social groups can cause tipping points in contagion flow

The distribution of group interactions in a social network affects the critical point at which explosive jumps in opinion, popularity, or disease spread occur. Contagion processes, such as opinion formation…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close