5,5 millions for project on smart matrices for knee cartilage repair

Worldwide millions of people suffer from knee osteoarthritis Symbolic picture: Prof. Lutz Dürselen

A research project in cartilage regeneration, in which the Institute of Orthopaedic Research and Biomechanics at Ulm University participates together with partners from eight european countries, was recently financed by the European Commission with 5.5 million Euro.

Named RESTORE, the project aims to create 3D matrices incorporating smart nanomaterials to repair knee cartilage lesions thereby reducing or delaying the onset of osteoarthritis, which currently affects 242 million people worldwide.

These matrices, explains Meriem Lamghari, researcher at “Instituto de Investigação e Inovação” ( i3S) and the coordinator of this European consortium, “are tailored so that they can be implanted and fill the injury site as well as respond to the knee joint mechanical forces.

Moreover, they contain smart nanoparticles with regenerative, anti-inflammatory and anti-microbial properties.

The nanoparticles with regenerative properties can, whenever necessary, be remotely activated with non-invasive methods”. For that the project's team will develop a knee brace equipped with sensors capable of activating the nanoparticles present in the implanted matrix”.

The work developed by the Ulm University team, who will receive around 409 000 Euro, will concentrate on the biomechanical characterization of the matrices and on preclinical testing, explains Prof. Lutz Dürselen from the Institute of Orthopaedic Research and Biomechanics in Ulm.

RESTORE emerges following constructive discussions between orthopaedic surgeons, tissue engineers, materials researchers and cellular biologists to answer pressing clinical needs. Therefore, explains Meriem Lamghari, “we are proposing two matrices, one based on a polymer already clinically tested in the veterinary sector, namely in large animals, for large knee cartilage lesions; and another matrix generated using bioprinting technology, composed by cartilage cells of human origin to which we will also incorporate the smart nanoparticles. This matrix is more adequate for small lesions”.

The consortium, which will develop the project during the next 44 months with the participation of partners from Portugal, Spain, Italy, Iceland, Norway, Sweden and Finland, will work together with the Institute of Orthopaedic Research and Biomechanics at Ulm University (Director: Prof. Anita Ignatius)

Text with material from Meriem Lamghari, Instituto de Investigação e Inovação (i3s), Universität Porto, Portugal

Prof. Dr. Lutz Dürselen: 0731/500-55333, lutz.duerselen@uni-ulm.de

Media Contact

Annika Bingmann idw - Informationsdienst Wissenschaft

Weitere Informationen:


Alle Nachrichten aus der Kategorie: Awards Funding

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

An artificial cell on a chip

Researchers at the University of Basel have developed a precisely controllable system for mimicking biochemical reaction cascades in cells. Using microfluidic technology, they produce miniature polymeric reaction containers equipped with…

Specific and rapid expansion of blood vessels

Nature Communications: KIT researchers identify a new mechanism to control endothelial cell size and arterial caliber – basis for better treatment of heart infarct and stroke. Upon a heart infarct…

Climate change drives plants to extinction in the Black Forest in Germany

Climate change is leaving its mark on the bog complexes of the German Black Forest. Due to rising temperatures and longer dry periods, two plant species have already gone extinct…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.