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The invention relates to a sample holder to be used in cryo fluorescence microscopes or to simply and cost effectively upgrade a room temperature fluorescence microscope. The holder solves existing problems regarding thermal and mechanical stability of the sample and allows for a localization accuracy of a few hundred Angstroms.
A new embodiment of a braiding machine was developed at the Institute of Aircraft Design (IFB) of Stuttgart University. It features a thread positioning unit which forms a secondary ring of horn-gears close to the braiding point. This secondary ring moves synchronously with the primary horn-gears of the braiding machine. Therefore, the position of each thread, that is close to the mandrel, is clearly defined. This is a basic requirement for manipulation of specific threads during the braiding process, which in turn permits the automated production of components with highly varying diameters at a constant braid angle.
The agonistic prodrug Fingolimod (FTY720) en-abled the first oral treatment of relapsing-remitting multiple sclerosis by modulating sphin-golipid signaling. Scientists developed novel Fingolimod non-prodrug derivatives, which re-duce the blood-brain-barrier leakage and blood T lymphocytes. Advantageously one derivative is fully active in the absence of sphingosine ki-nase 2 while exhibiting comparable activity to Fingolimod.
Scientists from Goethe University Frankfurt developed a new mobile device to determine ad-hoc coagulation times from full-blood samples utilizing "surface acoustic waves". This coagulation time is of high importance e.g. during emergency situations when the coagulation status of a patient under anticoagulant therapy needs rapid evaluation.
Moguntinones, a class of small molecule compounds comprise 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives with tumor and vascular targeting properties. The present invention relates to the use of Moguntinones for treatment of colorectal or gastric adenocarcinoma.
Tumor growth and metastasis are highly associated with the overexpression of protein kinases. Therefore protein kinases are an interesting class of target molecules for improved therapeutic attempts. These proteins are known to regulate the majority of cellular pathways including such relevant for control cell growth, movement and death - all processes relevant for cancer growth and progression.
A physiological process focused on in development of anti-cancer agents is apoptosis, a controlled form of cell death eliminating damaged, aberrant, infected, old or superfluous cells. In particular often mucosa tissue such as gastrointestinal mucosa is characterized by a rapid epithelial cell turnover in which homeostasis is maintained predominantly by apoptosis.
One essential prerequisite for growth and metastasis of cancers which form tumors is angiogenesis, a process involving the formation of new blood vessels from pre-existing capillary endothelial cells. Tumor cells may enhance angiogenesis by overexpression of proangiogenic factors, e.g. VEGF or interleukins. In general, this is especially pronounced with tumors having a high microvessel density as well as a particular aggressive behavior and high tendency to metastasize. Therefore, inhibitors of angiogenesis are researched as antitumor agents.
The present invention addresses the AD-converter in the receiver which is in respect to power consumption a highly crucial component. By reducing the resolution down to 1 bit and simultaneously improving the signal-to-noise ratio by a new demodulator concept the invention offers a cost and power efficient design for the RF front-end.
Eye drops of blood serum are an established and very effective therapeutic agent in many ophthalmological diseases such as keratitis and dry eye syndrome.The production of serum eye drops and the partition in one-day-doses must be operated under clean room conditions in order to prevent any contamination of the eye drops.
This product allows a fast and easy production of eye drops from blood serum without the need of a clean room laboratory. The single use product utilizes a closed system, which guaran-tees the sterility of the serum eye drops.
Electrical sensing array for the detection of multiple biological or chemical species in complex samples with applications e.g. in chemical analysis and medical diagnostics.
Such a device allows for simultaneous and spatiotemporal detection of concentration gradients in test samples. A direct integration of the proposed sensor array into many kinds of sensing platforms like microfluidics or lab-on-a-chip systems is possible and a combination with conventional optical read-out techniques can be realized.
Itaconic acid (ITA) - also known as methylenesuccinic acid or butanedioic acid - is one of the top 12 bio-based chemical building blocks and thus a promising platform compound for production of biofuels, chemical compounds, including e.g. detergents, and polymers, including plastics and artificial glass.
Itaconic acid (C5H6O4) is an organic dicarbonic acid which is soluble in water, ethanol, and acetone.
The new method for production of itaconic acid uses genes encoding for the itaconic acid biosynthesis pathway of the genus Ustilago maydis.
Invention of a stretcher on wheels for rescuing persons on big events with increased ease of operation for the rescue staff. The retractable cover protects the patient from rain and looks of bystanders.
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Die letzten 5 Focus-News des innovations-reports im Überblick:
In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...
The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.
As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...
Method produced by UI researcher could improve reaction time to deadly, expensive quakes
When an earthquake hits, the faster first responders can get to an impacted area, the more likely infrastructure--and lives--can be saved.
The Atlantic overturning is one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards. Also known as the Gulf Stream system, it is responsible for the mild climate in northwestern Europe.
Scientists now found evidence for a slowdown of the overturning – multiple lines of observation suggest that in recent decades, the current system has been...
Because they are regularly subjected to heavy vehicle traffic, emissions, moisture and salt, above- and underground parking garages, as well as bridges, frequently experience large areas of corrosion. Most inspection systems to date have only been capable of inspecting smaller surface areas.
From April 13 to April 17 at the Hannover Messe (hall 2, exhibit booth C16), engineers from the Fraunhofer Institute for Nondestructive Testing IZFP will be...