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For the inhibition of inflammatory immune responses: Novel degradation-stable inhibitors of the cPLA2

The invented substances have been characterized with regard to the inhibition of the cPLA2 (IC50 in the submicromolar range) and metabolic stability (tested in rat liver homogenates). The inventors are currently conducting such experiments with further, newly generated derivatives of the same inhibitor family. On behalf of the Westfalian Wilhelms-University of Muenster, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development. The cPLA2 has been identified as target for the inhibition of inflammatory immune responses. The invented substances are of high interest for any pharma company with an immunological pipeline and may constitute the first-in-class cPLA2 inhibitors for systemic application. 29.01.2016 | nachricht Read more

Differential diagnosis of dementia with Lewy bodies and Parkinson’s disease

Parkinson's disease (PD) is a neurological movement disorder. Atypical Parkinson syndromes arise from other neurodegenerative diseases like Dementia with Lewy bodies (DLB). The accurate distinction between them is challenging. Our scientists developed a new diagnostic test to differentiate between DLB, PD and other neuropathies. 26.01.2016 | nachricht Read more

Thin film area scan device for hyperspectral imagers

For two-dimensional film thickness determination, a measurement system based on a hyperspectral imager has been developed for the first time. A head forms a measurement line. Reflection of the measurement object is displayed on the entrance slit of the hyperspectral imager. From the spectral reflectance data of each locally resolvable pixel of the examined object the layer height is reconstructed. If the measurement object is moving uniformly, combined measurement lines are resulting in a two-dimensional measuring surface. In addition, for each locally resolvable pixel the distance between head and measurement object can be determined. 26.01.2016 | nachricht Read more

Peripherally acting NMDAR Antagonists as new Antidiabetic Medication

According to the International Diabetes Federation (IDF), diabetes affects close to 400 million people worldwide and caused 500 billion Euros in health expenditure in 2013. In preclinical and clinical trials, the NMDA receptor antagonist dextrorphan (DXO) and its prodrug dextromethorphan have been shown to harbor antidiabetic properties (Marquard et al., Nat Med 2015). In addition, DXO was shown to protect mouse and human pancreatic beta cells from cell death during a diabetogenic setting. DXO is well tolerated and sold as over-the-counter (OTC) medication for more than 50 years. However, adverse events are observed, which are likely caused by the action of DXO on the central nervous system (CNS). Here, the scientists developed DXO-derivatives that do not efficiently pass the blood brain barrier (BBB), and thus should cause fewer adverse effects on the CNS, but maintain their antidiabetic properties. Therefore, the derivatives might maintain the good safety profile and antidiabetic properties of its starting substance dextrorphan, but with fewer adverse effects. The inventors now aim to demonstrate the expected novel clinical benefit in clinical studies. 21.01.2016 | nachricht Read more

Device and Method for Improving a Person‘s Mobility

The present invention refers to a method and a device for improving a person‘s mobility. It is designed as a mobile, technical platform offering space for one person being moved with power assistance. In contrast to the already known mobility equipment, the technical basis of the inventive mobility platform consists of “rolling legs“ known as whegs (“wheg“ = wheel-like leg / wheel a leg / wheel-legs). These whegs combine the positive features of wheels and legs. To antagonize disturbing effects of alternation, a force coupled mechanical solution is applied. 21.01.2016 | nachricht Read more

Magnetic Alternating Current Imaging AFM

The invention relates to a method for AFM in which it is possible to measure magnetic information from single, isolated magnetic markers in on the scale of nm.The method is used to differentiate between marked and unmarked arrears, for measuring the magnetic AC-susceptibility of the marker and to determinate the geometry of a marker. Hereby the measured signal is further processed by an amplifier. The method utilises nanoparticles (marker), which are placed on or in a sample. Because of the alternating magnetic field these particles are stimulated to create a magnetic flow, which is dependent on the AC-susceptibility of the particle and on with the external alternat-ing field. With this effect, the entire magnetic flow in the area around the marker is changed. Furthermore, the entire sample is scanned in 2-D or 3-D and differences in the magnetic flow, which generate a magnetic interference, are measured by detecting the oscillation of the AFM tip. This oscillation is the measurement signal, which makes it possible to measure smaller magnetic interac-tions. 20.01.2016 | nachricht Read more

Cell reactor

The invention allows a selective extraction and analysis of cells from defined positions within natural or artificial three-dimensional structures without destroying the cell culture medium. This is achieved by a cell reactor having an upper part and lower part which are detachably connected together as well as inflow and outflow openings for liquid or gaseous nutrient medium. The flow through the cell culture with cell medium can be carried out both apically and basally. Furthermore, the reactor has a layer system with layer basket for receiving the cell culture carriers in the form of layers and positioning them along a fixing ring. The layers can have different geometric shapes and can be made out of different materials and are also reus-able. 20.01.2016 | nachricht Read more

Method and device for silicon filling of the eye

The invention describes a subsequent adaptive enlargement of the contact surface between the silicon oil and the retina for an optimal fit. This means that the size of the silicon oil bubble is adapted to fit to the volume of the eye socket. To achieve this, the inventor proposes to implant one or several biocompatible balloons together with the silicon oil into the eye. Those balloons absorb the water that is trying to fill the volume created by differences in the eye socket. By doing so, the balloon enlarges its volume and with this, and fills up the remaining space between silicon oil and the retina. Because of this, the retina is fully under pressure at all times. When the eye pressure rises, the balloons release the water. By doing so, the balloons are regulating the eye pressure and ensure adaptation to the varying volume of the eye socket. 20.01.2016 | nachricht Read more

Method for Cell monitoring

The invention describes a method and device to monitor cellular activity and vitality with higher accuracy than common methods. This method is based on measuring the specific cellular form and its development. To do so, several parameters are created, which interact with the neighbour cells and which are comparable over the course of the monitoring. The monitoring is done by recording the cellular movement and growth by video recording through a microscope. At the start of the compatibility testing, the substrate or material and the cells are brought together and get monitored over the course of 4 to 12 hours. All changes to the cells get recorded via video. After this, the entirety of the movement data from the cells is compared with reference data from tests with similar substrates. By doing so the invention delivers infor-mation about effect and toxicity of the tested substrate or material. 20.01.2016 | nachricht Read more

Quantitative prediction of the date of delivery of production animals

Even today it is possible to provide quantitative information about the beginning of birth by using simple sensors. The invention supplements warnings with information on the probable beginning of the birth. These quantitative predictions are based on the indirect measurement of prenatal anxiety in animals. Such agitation can be expressed in vocalization, locomotion and interaction. This can be measured by using acoustic-, light-, ultrasonic- or radar- sensors. The prediction itself is based on empirically proven assumptions about the natural history of the measured parameters during the prenatal period. Parameters such as age-related differences are taken into account. 20.01.2016 | nachricht Read more
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Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New study: How stable is the West Antarctic Ice Sheet?

Exceeding critical temperature limits in the Southern Ocean may cause the collapse of ice sheets and a sharp rise in sea levels

A future warming of the Southern Ocean caused by rising greenhouse gas concentrations in the atmosphere may severely disrupt the stability of the West...

Im Focus: Superconductivity: footballs with no resistance

Indications of light-induced lossless electricity transmission in fullerenes contribute to the search for superconducting materials for practical applications.

Superconductors have long been confined to niche applications, due to the fact that the highest temperature at which even the best of these materials becomes...

Im Focus: Wbp2 is a novel deafness gene

Researchers at King’s College London and the Wellcome Trust Sanger Institute in the United Kingdom have for the first time demonstrated a direct link between the Wbp2 gene and progressive hearing loss. The scientists report that the loss of Wbp2 expression leads to progressive high-frequency hearing loss in mouse as well as in two clinical cases of children with deafness with no other obvious features. The results are published in EMBO Molecular Medicine.

The scientists have shown that hearing impairment is linked to hormonal signalling rather than to hair cell degeneration. Wbp2 is known as a transcriptional...

Im Focus: From allergens to anodes: Pollen derived battery electrodes

Pollens, the bane of allergy sufferers, could represent a boon for battery makers: Recent research has suggested their potential use as anodes in lithium-ion batteries.

"Our findings have demonstrated that renewable pollens could produce carbon architectures for anode applications in energy storage devices," said Vilas Pol, an...

Im Focus: Automated driving: Steering without limits

OmniSteer project to increase automobiles’ urban maneuverability begins with a € 3.4 million budget

Automobiles increase the mobility of their users. However, their maneuverability is pushed to the limit by cramped inner city conditions. Those who need to...

All Focus news of the innovation-report >>>

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