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Whole cell-catalyst for the stereo- and regioselective production of 16-ß-OH Testosterone

Background Biocatalysts that can perform stereo- and regioselective hydroxylation of steroids are of great interest, since these molecules are among the most strongly marketed compounds of the pharmaceutical industry. Especially the human metabolites 16-ß-OH-Testosterone and Androstendion are desired products, as they have a wide application as food, dietary supplements and medical products or in terms of diagnostics. Testosterone can be metabolized by various human microsomal cytochrome P450 systems to the corresponding 16-ß-OH metabolite. So far, these enzymes are not capable of a regio- and stereoselective hydroxylation of testosterone. More than that, mammalian P450 systems are characterized by low stability and activity as well as an unpleasant expression level when compared to bacterial P450 systems. Invention Biochemists and pharmaceutical biologists of Saarland University have developed an effective recombinant biotransformation system based on a Bacillus megaterium strain that is capable of performing both stereo- and regioselective hydroxylation of non-activated carbon atoms of testosterone giving rise to 16-ß-OH-Testosterone in one step. The biocatalyst can further be applied in the synthesis of Androstendion using testosterone as a starting material. Advantages • Very fast and cost-efficient synthesis of steroid derivatives • One step transformation of testosterone into 16-ß-OH testosterone • No side products • High yield 06.10.2015 | nachricht Read more

Biocatalyst for the production of 25-OH-Vitamin D3 and other derivatives by recombinant Bacillus megaterium strains

Background The biotechnological production of 25-OH Vitamin D3 is of great importance, as this inactivated position 25 within vitamin D3 is hardly achievable by means of organic synthesis, especially in terms of a regio- and stereoselective manner. Within the human body, 25-OH vitamin D3 is converted into the biological active form of vitamin D3 which is important for the Ca2+ deposit into bones. Furthermore, in case of hepatic cirrhosis, its substitution is essential. It has anti-carcinogenic effects and acts protective in terms of autoimmune and cardiovascular diseases. 25-OH vitamin D3 is also used as a standard in clinical laboratory diagnostics. Altogether, 25-OH vitamin D3 is valuable concerning biotechnology, pharmacy and medicine. Invention Biochemists of Saarland University identified and optimized two cytochrome P450 systems which are capable of performing a regio- and stereoselective hydroxylation of vitamin D3 in one step, transferring vitamin D3 to 25-OH and other hydroxyl- derivatives of vitamin D3. The enzymes belong to the CYP109 family. One of these enzymes is capable of synthesizing 25-OH vitamin D3 as a major product and three side products in vitro producing a yield of 26 mg/l/24h. The second one gives rise to 25-OH vitamin D3 as the only product producing a yield of 5 mg/l/24h. Advantages • Synthesis of 25-OH vitamin D3 and other hydroxyl-derivatives in high yields o 25-OH vitamin D3 and three side products→ 26 mg/l/24h o 25-OH vitamin D3 → 5 mg/l/24h • Low production costs • No toxic side products as in classical organic synthesis 06.10.2015 | nachricht Read more

Agitation module for automated freeze

In freeze substitution the water content in biological samples is replaced with a solvent (usually acetone or methanol) and is a notoriously slow technique. This invention significantly reduces the duration by agitating samples during the process. 05.10.2015 | nachricht Read more

GSTP1 - A novel Approach for Prevention and Treatment of Heart Failure

Glutathione S-transferase P1 (GSTP1), applied as a recombinant protein, shows powerful longterm cardioprotective effects in a rat model for myocardial infarction after a single application within 2 hours after infarction. 05.10.2015 | nachricht Read more

Eukaryotic In Vivo Reaction Compartments

Biotechnological expression of highly active proteins or small chemical compounds of pharmaceutical relevance is often difficult. Many proteins or molecules of interest (POIs/MOIs) have cytotoxic side effects and interfere with the host’s metabolism. The invention provides a versatile tool - based on a low-temperature inducible protein accumulation system (lt-degron) - and methods to generate so-called ‘phenotypes on demand’ for the production of POIs/MOIs in a spatial and time-dependent manner ensuring proper posttranslational modifications. For the first time, it has been adopted to multicellular organisms like insects and intact plants in vivo. 02.10.2015 | nachricht Read more

Novel Inhibitors of Malassezia pachydermatis

Fungi (yeast) of the genus Malassezia are found on the skin of most humans and animals. In humans this disease is most commonly caused by Malassezia furfur. Infections with this pathogen can result in life-threatening fungemia and other nosocomial infections. Rare cases can be attributed to M. pachydermatis. Novel natural substances are provided, which show highly promising activity against M. pachydermatis. MIC values are comparable to those for terbinafine, which is a synthetic antifungal. 02.10.2015 | nachricht Read more

Therapy of brain tumors by inhibition of nuclear receptor tailles (Tlx)

DKFZ researchers identified nuclear receptor tailles (Tlx) as a valuable drug target for brain tumors especially gliobastomas. In vivo experiments showed almost doubling in survival time of mice harbouring brain tumors by inhibiting the expression of Tlx in tumor cells. In addition a highly significant correlation between expression of Tlx in brain tumor cells and survival of the patient was demonstrated. 30.09.2015 | nachricht Read more

ACIP / Peptide-based Inhibition of Cancer Cachexia

Cachexia related to cancer, occurs in 30-70% of cancer patients and still represents an as-yet non-curable and fatal paraneoplastic syndrome in a variety of tumor entities. The present invention discloses a new method for preventing cancer cachexia based on preventing inhibition of the protein AMPK. 30.09.2015 | nachricht Read more

miRNA-375 and miRNA-141 as non-invasive markers for diagnosis and staging in prostate cancer

6% of all prostate cancer patients die due to their illness. However, 80% of all prostate cancer patients do not need therapy, since their cancers grow slowly. Since the mainly used marker (prostate-specific antigen, PSA) is also elevated in case of inflammatory processes or with benign prostatic hyperplasia, DKFZ inventors analysed serum samples and identified miRNA-375 and miRNA-141 as new biomarkers for high-risk tumors. 30.09.2015 | nachricht Read more

Synthetic lignans targeting cardiovascular diseases

Novel synthetic lignans to affect inflammatory processes related to surgical cardiovascular intervention have been identified. The compounds may have highly beneficial effects for preparation of cardiac by-pass implants as well as for stent conduits. 28.09.2015 | nachricht Read more
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Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Physicists shrink particle accelerator

Prototype demonstrates feasibility of building terahertz accelerators

An interdisciplinary team of researchers has built the first prototype of a miniature particle accelerator that uses terahertz radiation instead of radio...

Im Focus: Simple detection of magnetic skyrmions

New physical effect: researchers discover a change of electrical resistance in magnetic whirls

At present, tiny magnetic whirls – so called skyrmions – are discussed as promising candidates for bits in future robust and compact data storage devices. At...

Im Focus: High-speed march through a layer of graphene

In cooperation with the Center for Nano-Optics of Georgia State University in Atlanta (USA), scientists of the Laboratory for Attosecond Physics of the Max Planck Institute of Quantum Optics and the Ludwig-Maximilians-Universität have made simulations of the processes that happen when a layer of carbon atoms is irradiated with strong laser light.

Electrons hit by strong laser pulses change their location on ultrashort timescales, i.e. within a couple of attoseconds (1 as = 10 to the minus 18 sec). In...

Im Focus: Battery Production: Laser Light instead of Oven-Drying and Vacuum Technology

At the exhibition BATTERY + STORAGE as part of WORLD OF ENERGY SOLUTIONS 2015 in Stuttgart, the Fraunhofer Institutes for Laser Technology ILT and for Ceramic Technologies and Systems IKTS will be showing how laser technology can be used to manufacture batteries both cost- and energy-efficiently.

In the truest sense, it’s all about watts at the Dresden-based Fraunhofer Institute for Ceramic Technologies and Systems IKTS and the Aachen-based Fraunhofer...

Im Focus: New Sinumerik features improve productivity and precision

EMO 2015, Hall 3, Booth E06/F03

  • Drive optimization called automatically by the part program boosts productivity
  • Automatically switching the dynamic values to rapid traverse and interpolation...
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