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Parenteral controlled drug delivery - polymers

Parenteral controlled drug delivery is of crucial importance for the pharmacotherapy of many diseases (e.g. breast and prostate cancer, local inflammation). By means of controlled release systems it is possible to decrease the frequency of administration (from hours to months), to increase drug efficiency and to decrease side effects. The problem is solved by providing Direct Injectable Polymer Solutions (DIPOs) which act as a depot after administration. Their polarity and degradation rate is adjustable. They are much less acidic compared to PLA/PLGA polymers. 10.02.2017 | nachricht Read more

MCR Dendrimers

Dendrimers are spherical, highly branched polymers used in the fields of drug delivery and drug targeting, DNA/RNA delivery, imaging, protein labelling, protein crosslinking and protein separation, coagulation inhibition, and surface, cell and tissue recognition. They are also used as macroamphiphiles and catalyst supports. All previously existing dendrimers require special, branched and partially protected or polyreactive building blocks for their synthesis. A disadvantage is the limited range of dendrimers with varying structures that can be produced, and the concentration to few dendron forming functional groups. The new technology offers the possibility of synthesising dendrimers with almost any combination of branch lengths, degree of branching, internal and terminal groups. This is achieved by means of multiple iterative multicomponent reactions, e.g. with acidic, alkaline, hydrophilic, lipophilic, sugar and other functional groups. 10.02.2017 | nachricht Read more

Low cost cloning

DNA assembly methods such as such as Gibson and Golden Gate cloning are basic tools for synthetic biology. Both methods allow assembly of constructs from multiple DNA fragments in a one-pot one-step assembly reaction. Standardization of parts is another essential element of modern synthetic biology. A novel method has been developed to assemble constructs from several individual DNA parts - each kept on a solid carrier - directly in a one-pot one-step reaction. 10.02.2017 | nachricht Read more

Parenteral controlled drug delivery - oleogels

Parenteral controlled drug delivery is of crucial importance for the pharmacotherapy of many diseases (e.g. breast and prostate cancer, local inflammation). By means of controlled release systems it is possible to decrease the frequency of administration (from hours to months), to increase drug efficiency and to decrease side effects. Direct Injectable OleoGels (DIOGs) and In Situ Forming OleoGels (ISFOGs) were developed as new, biodegradable and lipid based formulations for parenteral controlled release applications. Both formulations have many advantages in terms of manufacturability, rheological properties and release control compared to the currently used drug delivery systems. 10.02.2017 | nachricht Read more

Barley yellow mosaic virus

Yellow mosaic virus disease leads to substantial losses - up to 50 % of the yield - in susceptible barley varieties (Hordeum vulgare). The disease is caused by different strains of Barley yellow mosaic virus (BaYMV) and Barley mild mosaic virus (BaMMV). It cannot be cured by chemical treatment. The present invention provides a new recessive resistance gene. Variants of the gene lead to resistance against all agents known to cause yellow mosaic virus disease in Europe. 10.02.2017 | nachricht Read more

Night Vision Algorithm

The Technology provides a new and outstanding method for the enhancement of the quality of dim images. Inspired by the spatial integration of visual information in nocturnal insects, the algorithm successfully enhances the contrast and brightness of dim images and removes noise while preserving fine details and object contours. The patented system is applicable to field programmable gate arrays (FPGA) or image processors, which offer parallel computing capabilities. A wide variety of capabilities and markets from automotive sector to the enhancement of diagnostic images can be addressed. 08.02.2017 | nachricht Read more

Anemometers to measure microturbulences

Researchers from the University of Oldenburg, Germany, developed a laser cantilever anemometer (LCA) which utilizes the laser pointer principle of a scanning-force microscope to capture the velocity and the angle of fluid flows. 07.02.2017 | nachricht Read more

Quantification of hydrogen - method that uses a flame ionization detector to dermine hydrogen

The Carl von Ossietzky University in Oldenburg, Germany, developed a method which markedly improved the quantitative determination of hydrogen. A so-called TPR is conducted by coupling a flame ionization detector (FID) to a methanizer. Adding a certain amount of carbon monoxide (CO) and an excess amount of hydrogen immediately upstream of the FID, CO will react with hydrogen to yield methane. Methane produces a FID signal which is proportional to the amount of hydrogen in the sample. 07.02.2017 | nachricht Read more

Multisensor system - optical device to analyze liquid media

As yet there has been no satisfactory and easy method to determine the concentrations of substances dissolved in liquid product flows. Previous methods using sensors were not sufficiently reliable and not designed for flow-through systems. Or they required that the analyte whose concentration was to be determined was already known. The device according to invention makes it easy to determine the analyte in a liquid phase both qualitatively and quantitatively. The Carl von Ossietzky University in Oldenburg, Germany, developed a method which serves the purpose of identifying and quantifying substances (proteins, amino acids, drug constituents) in solution. 07.02.2017 | nachricht Read more

Adjustable flaps for wind turbines

Researchers at the University of Oldenburg have developed a flap for wind turbine generators which is mounted parallel to the main rotor blade and is considerably smaller in its size and mass than the main blade. The core piece of the invention is the adjustable pitch of the flap. The flap's pitch as well as its distance to the main blade can be swiftly adjusted to actual wind variations by means of a control unit or adaptive mechanics, thus assuring an optimal airflow at the site of the main rotor. The flap adjustment unit is able to consider the position of the main blade, the actual rotor rotation speed, and the actual wind speed. A purely mechanical adaptive pitch adjustment is also in a state of planning. 03.02.2017 | nachricht Read more
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Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

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Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
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