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Future electro-mobility concepts require advanced battery technologies. Main drawbacks today are restrictions in energy density, cycling stability, and cost. The presented invention provides a solution that helps to overcome these problems. Extensive laboratory tests have already demonstrated the advantages of the invented process for preparing lithium-ion battery electrodes. Further improvement is currently under development. PROvendis offers licenses for this invention to interested companies on behalf of the University of Muenster, Germany.
Perfusion analysis in animal models (e.g. myocardial infarction) is currently determined by using fluorescent particles or dyes that are injected into circulation. They distribute throughout all blood vessels and stain them permanently. Thus it is possible to distinguish areas that are supplied with blood and those that are not. Since the dyes are long-lasting in the tissues they interfere with subsequent methods of analysis. A model animal that is used for perfusion analytics can therefore only be used for this specific analytical method.
The present invention overcomes these drawbacks by injecting non fluorescent inert particles that are the first component of an orthogonal system. After perfusion with these particles, the second component is added to frozen tissue sections of interest. Thus, perfusion analysis is solely performed on a selected tissue section, without any limitations for the remaining tissue.
This approach allows a background-free subsequent tissue analysis, optimizes data harvest, is economic and reduces animal consumption.
The invention relates to the usage of a tunable, resonant electromagnetic field for both, the targeted fabrication of structures with dimensions smaller than the used beam diameter and the targeted fabrication of ultra small particles. Therefor the electromagnetic field that is created by an ultra short laser pulse on the surface of an object is superposed with an external field to achieve a resonance rise specific to the processed material.
The object of this invention was to develop a sealing material that allows the transport of flower arrangements in a suitable vessel with continuous liquid contact. To achieve this, a suitable transport vessel is filled with water and the flowers are placed into it. Then, a hydrophobic substance with a density of <1 g/cm3, like a suitable grease, is applied in liquid form into the vessel. The grease floats on the water surface, penetrates between the stems and solidifies. Afterwards a water-containing liquid is applied on this layer and penetrates between the stems, too. Finally it solidifies into a gel with sufficient stability. The method allows an uninterrupted supply of water, nutrients and fresh-keeping agents for the flowers. As a result, the durability of the flowers will be increased under certain circumstances.
Researchers at Reutlingen University have succeeded in developing a label-free method for the characterization of metaphase chromosomes. The method and the corresponding analysis algorithm allow for visualization of both the chemical properties (absorption) and the morphological properties (stray light) of a chromosome. Using this method, the bands and sub-bands can be characterized with high resolution. Thus, no staining is required for unambiguous identification. The technology can be integrated into all imaging methods (e.g.microscopy).
The invention offers a method to create and use electronic coupons in a new way. The coupons can be spread both directly between smartphones and by means of social networks or by means of classical advertisement, such as posters or fliers. The value of each single coupon can be increased by sharing it, initiating a viral distribution by rewarding the users for the sharing. As each coupon is unique, statistics can be performed allowing insight on the acceptance, use and distribution ways of every used coupons, allowing insight in the own mobile couponing procedures on a new level.
The present invention provides compounds acting as an effective and selective medicament for the treatment of neoplastic diseases or proliferative disorders, in particular compounds which induce selectively apoptosis of degenerated cells providing reduced side effects in living organisms. The compounds of the present invention are characterized by a high selectivity towards neoplastic cells. CLL cells show a higher sensitivity towards the compounds than PBMCs opening a therapeutic window. The EC50 for CLL cells is in the lower micromolar range.
The invention reveals a cost effective method for intensity-modulated radiotherapy (IMRT). Using common 3D printer technology a template based on patients tumor shape is generated, which can be used for defining the position of the individual leaves of a multi leave collimator.
So far the analysis of indoor concentrations of formaldehyde is only possible via expensive methods, normally requiring GC or HPLC analysis in the lab. So called MOX (metal oxide) sensors theoretically permit an online-monitoring, but there is so far no instrument available for the detection of relevant concentrations in the ppb-range at reasonable costs.
Our invention presents a novel MOX-sensor based on In4Sn3O12 as sensitive layer with sensitivities for formaldehyde being two orders of magnitude above those of established reference sensors. Our sensor allows an online/realtime-monitoring of formaldehyde in day to day settings, at low cost.
Cancer patients frequently bear therapeutically relevant genome alteration. For instance, lung adenocarcinomas of patients that have never smoked carry genome alterations affecting kinases, such as EGFR mutations and translocations affecting ALK, ROS1, and RET genes. These patients can be effectively treated with an ever-growing number of kinase inhibitors. However, despite substantive cancer genome sequencing efforts a majority of tumors still lacks therapeutically tractable alterations. Scientists of the University of Cologne identified NRG1 gene fusions as ideal diagnostic and prognostic markers and targets for various tumours. The MTSS1-NRG1 fusion event has e.g. been detected in patients with small cell lung cancer and the gene fusion CD74-NRG1 has been shown to occur frequently in never smokers with invasive mucinous lung adenocarcinoma lacking KRAS mutation. The latter has been verified by several other groups.
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