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An der Hochschule für Technik und Wirtschaft des Saarlandes (HTW
Saar) wurde nun ein System entwickelt, dass die Möglichkeiten erdgedeckter Flüssiggas-tanks optimal aus nutzt und so eine substanzielle Energie-und Kosteneinsparung generiert. Die entscheidende Innovation besteht darin, dass flüssiggas betriebene Blockheizkraftwerk (BHKW) mit einer Wärmepumpe zu koppeln, wobei der Gastank außer zur Speicherung des Flüssiggases gleichzeitig
als Erdwärmekollektor und Verdampfer für die Wärmepumpe genutzt wird. Dies ist nur bei einem erdgedeckten Tank sinnvoll möglich.
Das Flüssiggas dient im laufenden Betrieb gleichzeitig als Kraftstoff und als Kältemittel. Die erfindungsgemäße Anlage trägt auf diese Weise dazu bei, Betriebskosten zu reduzieren und die Energieeffizienz des Systems zu steigern. Da die verwendeten Komponenten bis auf wenige Bauteile mit denen eines herkömmlichen flüssiggasbetriebenen BHKW übereinstimmen, kann auf einfache Weise und ohne die Anschaffung separater Wärmekollektoren ein deutliches Einsparpotenzial nutzbar gemacht werden. Modellrechnungen
ergeben eine Reduktion des Kraftstoffverbrauchs von bis zu 40%.
Die Optimierung des gesamten Systems im Hinblick auf die verschieden Betriebsparameter ist Gegenstand einer aktuellen Prototypenstudie.
The presented method combines the advantages of a highly specific and sensitive immunological sensor surface with the extensive detail of an infrared spectroscopic analysis, with particular regard to the secondary structure analysis of protein biomarker candidates. Every non-clotting, cell-free fluid is analyzable.
The Institute of Aircraft Design (IFB) at the University of Stuttgart developed a flexible pressure roll mechanism for braiding machines, which significantly improves the automated braiding of components with sharp curvatures and widely varying cross-sections without the need for manual intervention. While overbraiding a mandrel the flexible mounting of the pressure rolls allows for adaptation to the mandrel's positioning (e.g. inclined position) and to changes in the cross section. They exert a constant and precisely defined force on the braid and thereby press it against the mandrel.
As part of the automated process, the robot control of the braiding machine coordinates the movement of the pressure rolls. This significantly improves the braiding of components with a variable cross-section and curvatures so that manual intervention is no longer required.
Based on a very thin, high-strength design of the invention the ultrasonic sensor is placed between the teeth of the approximal region, thus reducing the distance significantly. As a result the images posses a very high spatial resolution.
The ultrasonic sensor consists of a metallic base plate with a reinforced frame, made of high-strength pure titanium or a TiAl6V4 alloy. The edges of the frame are rounded to make the insertion in the approximal region more comfortable. The total thickness of the design is limited to a maximum of 0.8 mm. The piezoelectric part is made on a PVDF-film equipped with spacers and shielded by an adjustable cover. The cover allows for a special contact by respecting the safety clearance to the teeth. By removing the cover hydrogel is pumped into the gap to provide acoustic coupling. In addition, it is used for lubrication of the cover movement.
Scientist at the Westfälische Wilhelms University of Münster developed the efficient Cu-catalyzed PEN method for the formation of tetra-substituted pyrazoles. In this atomeconomic process, readily available enamines and nitriles are reacted by C-C and N-N bond formation. A broad scope of enamines and nitriles can be utilized in this process.
The invention relates to a sample holder to be used in cryo fluorescence microscopes or to simply and cost effectively upgrade a room temperature fluorescence microscope. The holder solves existing problems regarding thermal and mechanical stability of the sample and allows for a localization accuracy of a few hundred Angstroms.
A new embodiment of a braiding machine was developed at the Institute of Aircraft Design (IFB) of Stuttgart University. It features a thread positioning unit which forms a secondary ring of horn-gears close to the braiding point. This secondary ring moves synchronously with the primary horn-gears of the braiding machine. Therefore, the position of each thread, that is close to the mandrel, is clearly defined. This is a basic requirement for manipulation of specific threads during the braiding process, which in turn permits the automated production of components with highly varying diameters at a constant braid angle.
The agonistic prodrug Fingolimod (FTY720) en-abled the first oral treatment of relapsing-remitting multiple sclerosis by modulating sphin-golipid signaling. Scientists developed novel Fingolimod non-prodrug derivatives, which re-duce the blood-brain-barrier leakage and blood T lymphocytes. Advantageously one derivative is fully active in the absence of sphingosine ki-nase 2 while exhibiting comparable activity to Fingolimod.
Scientists from Goethe University Frankfurt developed a new mobile device to determine ad-hoc coagulation times from full-blood samples utilizing "surface acoustic waves". This coagulation time is of high importance e.g. during emergency situations when the coagulation status of a patient under anticoagulant therapy needs rapid evaluation.
Moguntinones, a class of small molecule compounds comprise 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives with tumor and vascular targeting properties. The present invention relates to the use of Moguntinones for treatment of colorectal or gastric adenocarcinoma.
Tumor growth and metastasis are highly associated with the overexpression of protein kinases. Therefore protein kinases are an interesting class of target molecules for improved therapeutic attempts. These proteins are known to regulate the majority of cellular pathways including such relevant for control cell growth, movement and death - all processes relevant for cancer growth and progression.
A physiological process focused on in development of anti-cancer agents is apoptosis, a controlled form of cell death eliminating damaged, aberrant, infected, old or superfluous cells. In particular often mucosa tissue such as gastrointestinal mucosa is characterized by a rapid epithelial cell turnover in which homeostasis is maintained predominantly by apoptosis.
One essential prerequisite for growth and metastasis of cancers which form tumors is angiogenesis, a process involving the formation of new blood vessels from pre-existing capillary endothelial cells. Tumor cells may enhance angiogenesis by overexpression of proangiogenic factors, e.g. VEGF or interleukins. In general, this is especially pronounced with tumors having a high microvessel density as well as a particular aggressive behavior and high tendency to metastasize. Therefore, inhibitors of angiogenesis are researched as antitumor agents.
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Die letzten 5 Focus-News des innovations-reports im Überblick:
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