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Druggable oncogenic fusions - NRG1 Gene Fusions as Markers & Targets for Various Cancers

Cancer patients frequently bear therapeutically relevant genome alteration. For instance, lung adenocarcinomas of patients that have never smoked carry genome alterations affecting kinases, such as EGFR mutations and translocations affecting ALK, ROS1, and RET genes. These patients can be effectively treated with an ever-growing number of kinase inhibitors. However, despite substantive cancer genome sequencing efforts a majority of tumors still lacks therapeutically tractable alterations. Scientists of the University of Cologne identified NRG1 gene fusions as ideal diagnostic and prognostic markers and targets for various tumours. The MTSS1-NRG1 fusion event has e.g. been detected in patients with small cell lung cancer and the gene fusion CD74-NRG1 has been shown to occur frequently in never smokers with invasive mucinous lung adenocarcinoma lacking KRAS mutation. The latter has been verified by several other groups. 30.01.2015 | nachricht Read more

AGIDC - Adaptive Grid Impedance Droop Control

Due to the increasing number of decentralized power feeder it becomes more and more difficult to keep up the stability of the power grid. For power feeder in low- and medium voltage power grid the ohmic part of the impedance gains more influence than in the transport grid. This means that the coupling of frequency and voltage to active and reactive power can be completely inverted compared to the common droop control. AGIDC solves this problem of droop control for decentralized power feeder in low- and medium voltage grids. AGIDC - with an impedance dependent static function - provides a droop control in a general form. The power feeding can be adapted to changing grid impedances and to other requirements from the transport grid. 29.01.2015 | nachricht Read more

EO-Silicon - Inducing the electrooptic effect in silicon

Because of the symmetrical crystal structure there is no electro-optical effect in silicon. That means that in silicon the refractive index is not dependent on the applied electric field strength. The manufacturing of electro-optical components in silicon technology was therefore not possible in a cost-effective way. A surprisingly simple and inexpensive method has now been found using chemical treatment of the silicon surface with bromine. Hereby silicon can be converted into an electro-optically active material. The induced electro-optical activity has a high thermal stability, which can even be increased by appropriate passivation layers. 21.01.2015 | nachricht Read more

Module for the generation of scheduled /time - defined chronological pressure gradients /histories

Die Erfindung dient zur Erzeugung von Druckpulsen, welche einen ventilgesteuerten Hoch- und Niederdruckbereich sowie einen Vordruckerzeugungsbereich umfassen. Ziel ist ein universelles und vielseitig einsetzbares Gerät, welches die Prüfnormen zuverlässig und reproduzierbar erfüllt. Dabei stehen Flexibilität, leichte Bedienung, Wirtschaftlichkeit, Zeit- und Kostenersparnis im Vordergrund. 20.01.2015 | nachricht Read more

Energy efficient, adaptive cups for medical technology and pharmaceutical products

Die Erfindung betrifft einen monolithischen (aus einem Bauteil bestehenden), geschlossenen, nachgiebigen Sauggreifer, mit dem glatte Objekte gegriffen, hantiert und transportiert werden können. 20.01.2015 | nachricht Read more

Product Explorer

Bei der Erfindung handelt es sich um ein graphisches System (Software mit technischem Hintergrund) zur schnellen Produktauswahl innerhalb aller Produkte eines Marktsegments. Diese Informationen liegen oft in tabellarischer Form oder in dedizierten Datenbanken vor und besitzen alle die gleichen Attribute aber in unterschiedlicher Ausprägung. Neben der Produktauswahl ermöglicht das System auch eine genaue Analyse des Marktsegments. Weitere Einsatzgebiete sind Visualisierungen beliebiger multidimensionaler Daten insbesondere von Simulationsergebnissen. 20.01.2015 | nachricht Read more

A regenerable molybdenum-containing oxidic ternary co-catalyst for efficient photocatalytic water splitting

A novel oxidic ternary co-catalyst containing molybdenum, which has been found to be highly active and stable in the overall photocatalytic splitting of water over gallium oxide. With this noble metal-free system a catalytic activity comparable to that of the well-established RhxCr2-xO3/Ga2O3 water splitting catalyst can be achieved. Furthermore, its activity can be easily regenerated resulting in a long service life. 20.01.2015 | nachricht Read more

Multifunctional construction textiles for non - destructive permanent moisture monitoring in timber and concrete structures

Der Erfindungsidee betrifft die Verwendung und die Herstellung von sensorischen Textilstrukturen, die gitterartig, strang-, bandförmig oder als Abstandsstrukturen ausgebildet sind. Selbige dienen gleichzeitig zur Armierung, Dämmung oder Dichtung sowie der Feuchtezustandsüberwachung von Holz- und Betonbauwerken. 20.01.2015 | nachricht Read more

Procedure and lighting /illuminating system for optical contrast enhancement

Das Ziel dieser Erfindung ist es, den Kontrast / Schärfe von erkennbaren Strukturen durch zeitlich und räumlich kontrolliertes Licht optisch zu verstärken. Dieser neuartige Ansatz soll die klassischen Methoden der Kontrastverstärkung ergänzen. Eine weitere Aufgabe der vorliegenden Erfindung besteht darin, eine einfache und kostengünstige Methode zu schaffen, statische High-Dynamic-Range (so genannte Bilder mit hohem Kontrastverhältnis) zu betrachten und dabei das Kontrastverhältnis, die wahrgenommene Tonauflösung und den Farbraum über die physikalischen Möglichkeiten der verwendeten Darstellungsmittel hinaus zu erhöhen. 20.01.2015 | nachricht Read more

H₂Oleum - Stable Water/Diesel Micro-emulsions > 95 % Reduction of Particulate Matter

H₂Oleum is an absolutely stable microemulsion and the first thermodynamically stable water/fuel emulsion ever – stable over an extremely wide range of temperatures and operating conditions. H₂Oleum is a bicontinuous microemulsion – i.e. both the oil and the water components form continuous domains within the liquid. H₂Oleum significantly saves surfactant and the water/fuel ratio can be freely varied. We offer and licenses and technical support for the commercialisation of H₂Oleum to innovative companies. Patent applications have been filed for H₂Oleum in Europe and North America. 15.01.2015 | nachricht Read more
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Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoscale Mirrored Cavities Amplify, Connect Quantum Memories

Advance could lead to quantum computing and the secure transfer of information over long-distance fiber optic networks

The idea of computing systems based on controlling atomic spins just got a boost from new research performed at the Massachusetts Institute of Technology (MIT)...

Im Focus: Shedding light on cold Higgs

For the first time physicists at the University of Stuttgart provide experimental proof of a stable and well-defined Higgs mode in superconductors – a direct analog to the Higgs particle, discovered only recently at the world´s largest particle accelerator, the Large Hadron Collider at the CERN – however, using not more than a table-top experiment.

When François Englert and Peter Higgs were awarded the 2013 Nobel Prize, a scientific breakthrough was honored that could hardly be more spectacular: born from...

Im Focus: Pictured together for the first time: A chemokine and its receptor

Researchers capture 3-D structure of a molecular interaction that influences cancer, inflammation and HIV infection

Researchers at University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences and the Bridge Institute at the University of Southern...

Im Focus: Intelligent Algorithm Finds Available Carsharing Vehicles

A new program will make it easier to combine different modes of transport. Siemens is developing a service for predicting the availability of carsharing vehicles at a given location at specific times.

The forecasting tool will be incorporated into the integrated SiMobility Connect mobility platform, which links carsharing firms, public transport companies,...

Im Focus: New conductive coatings for flexible touchscreens – presentation at nano tech 2015 in Japan

Mobile phones and smart phones still haven‘t been adapted to the carrying habits of their users. That much is clear to anyone who has tried sitting down with a mobile phone in their back pocket: the displays of the innumerable phones and pods are rigid and do not yield to the anatomical forms adopted by the people carrying them. By now it is no longer any secret that the big players in the industry are working on flexible displays. Properties that suitable coatings offer in this respect will be demonstrated by the developments of the INM – Leibniz-Institute for New Materials on show nano tech 2015, Tokio, Japan.

For the nanoparticle inks, the researchers are using what are known as TCOs, or transparent conducting oxides. “We use the TCOs to produce nanoparticles with...

All Focus news of the innovation-report >>>

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