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Variable number of threads in braiding machines

A new embodiment of a braiding machine was developed at the Institute of Aircraft Design (IFB) of Stuttgart University. It features a thread positioning unit which forms a secondary ring of horn-gears close to the braiding point. This secondary ring moves synchronously with the primary horn-gears of the braiding machine. Therefore, the position of each thread, that is close to the mandrel, is clearly defined. This is a basic requirement for manipulation of specific threads during the braiding process, which in turn permits the automated production of components with highly varying diameters at a constant braid angle. 16.03.2015 | nachricht Read more

Modulators of sphingolipid signaling for the treatment of multiple sclerosis

The agonistic prodrug Fingolimod (FTY720) en-abled the first oral treatment of relapsing-remitting multiple sclerosis by modulating sphin-golipid signaling. Scientists developed novel Fingolimod non-prodrug derivatives, which re-duce the blood-brain-barrier leakage and blood T lymphocytes. Advantageously one derivative is fully active in the absence of sphingosine ki-nase 2 while exhibiting comparable activity to Fingolimod. 13.03.2015 | nachricht Read more

Point-of-care monitoring of blood coagulation time via 'Surface Acoustic Waves' (SAW)

Scientists from Goethe University Frankfurt developed a new mobile device to determine ad-hoc coagulation times from full-blood samples utilizing "surface acoustic waves". This coagulation time is of high importance e.g. during emergency situations when the coagulation status of a patient under anticoagulant therapy needs rapid evaluation. 13.03.2015 | nachricht Read more

Moguntinones – a novel class of kinase inhibitors for cancer therapy

Moguntinones, a class of small molecule compounds comprise 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives with tumor and vascular targeting properties. The present invention relates to the use of Moguntinones for treatment of colorectal or gastric adenocarcinoma. Tumor growth and metastasis are highly associated with the overexpression of protein kinases. Therefore protein kinases are an interesting class of target molecules for improved therapeutic attempts. These proteins are known to regulate the majority of cellular pathways including such relevant for control cell growth, movement and death - all processes relevant for cancer growth and progression. A physiological process focused on in development of anti-cancer agents is apoptosis, a controlled form of cell death eliminating damaged, aberrant, infected, old or superfluous cells. In particular often mucosa tissue such as gastrointestinal mucosa is characterized by a rapid epithelial cell turnover in which homeostasis is maintained predominantly by apoptosis. One essential prerequisite for growth and metastasis of cancers which form tumors is angiogenesis, a process involving the formation of new blood vessels from pre-existing capillary endothelial cells. Tumor cells may enhance angiogenesis by overexpression of proangiogenic factors, e.g. VEGF or interleukins. In general, this is especially pronounced with tumors having a high microvessel density as well as a particular aggressive behavior and high tendency to metastasize. Therefore, inhibitors of angiogenesis are researched as antitumor agents. [Ref. UMZ252] 12.03.2015 | nachricht Read more

Method for demodulation and demodulator

The present invention addresses the AD-converter in the receiver which is in respect to power consumption a highly crucial component. By reducing the resolution down to 1 bit and simultaneously improving the signal-to-noise ratio by a new demodulator concept the invention offers a cost and power efficient design for the RF front-end. 10.03.2015 | nachricht Read more

Product for producing of serum eye drops (ESAT)

Eye drops of blood serum are an established and very effective therapeutic agent in many ophthalmological diseases such as keratitis and dry eye syndrome.The production of serum eye drops and the partition in one-day-doses must be operated under clean room conditions in order to prevent any contamination of the eye drops. This product allows a fast and easy production of eye drops from blood serum without the need of a clean room laboratory. The single use product utilizes a closed system, which guaran-tees the sterility of the serum eye drops. 05.03.2015 | nachricht Read more

Electrolyte-gated Sensor for Species Detection

Electrical sensing array for the detection of multiple biological or chemical species in complex samples with applications e.g. in chemical analysis and medical diagnostics. Such a device allows for simultaneous and spatiotemporal detection of concentration gradients in test samples. A direct integration of the proposed sensor array into many kinds of sensing platforms like microfluidics or lab-on-a-chip systems is possible and a combination with conventional optical read-out techniques can be realized. 05.03.2015 | nachricht Read more

Method for production of itaconic acid

Itaconic acid (ITA) - also known as methylenesuccinic acid or butanedioic acid - is one of the top 12 bio-based chemical building blocks and thus a promising platform compound for production of biofuels, chemical compounds, including e.g. detergents, and polymers, including plastics and artificial glass. Itaconic acid (C5H6O4) is an organic dicarbonic acid which is soluble in water, ethanol, and acetone. The new method for production of itaconic acid uses genes encoding for the itaconic acid biosynthesis pathway of the genus Ustilago maydis. 04.03.2015 | nachricht Read more

Versatile wheeled stretcher for rescuing of persons

Invention of a stretcher on wheels for rescuing persons on big events with increased ease of operation for the rescue staff. The retractable cover protects the patient from rain and looks of bystanders. 03.03.2015 | nachricht Read more

Temperature stabilisation of high-resolution microscopes

Temperaturstabilisierung ist bei hochauflösenden Mikroskopen sehr wichtig. Die von DKFZ entwickelte Technologie ermöglicht mit Durchstrom von exakt temperierter Flüssigkeit durch die Temperiereinheiten die genaue Regulation der Temperatur und somit eine Wärmeaufnahme und -abgabe am Mikroskopaufbau. 02.03.2015 | nachricht Read more
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Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Experiment Provides the Best Look Yet at 'Warm Dense Matter' at Cores of Giant Planets

In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...

Im Focus: Energy-autonomous and wireless monitoring protects marine gearboxes

The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.

As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...

Im Focus: 3-D satellite, GPS earthquake maps isolate impacts in real time

Method produced by UI researcher could improve reaction time to deadly, expensive quakes

When an earthquake hits, the faster first responders can get to an impacted area, the more likely infrastructure--and lives--can be saved.

Im Focus: Atlantic Ocean overturning found to slow down already today

The Atlantic overturning is one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards. Also known as the Gulf Stream system, it is responsible for the mild climate in northwestern Europe. 

Scientists now found evidence for a slowdown of the overturning – multiple lines of observation suggest that in recent decades, the current system has been...

Im Focus: Robot inspects concrete garage floors and bridge roadways for damage

Because they are regularly subjected to heavy vehicle traffic, emissions, moisture and salt, above- and underground parking garages, as well as bridges, frequently experience large areas of corrosion. Most inspection systems to date have only been capable of inspecting smaller surface areas.

From April 13 to April 17 at the Hannover Messe (hall 2, exhibit booth C16), engineers from the Fraunhofer Institute for Nondestructive Testing IZFP will be...

All Focus news of the innovation-report >>>

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World Conference On Regenerative Medicine 2015: Registration And Abstract Submission Now Open

25.03.2015 | Event News

University presidents from all over the world meet in Hamburg

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17.03.2015 | Event News

 
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