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Eukaryotic In Vivo Reaction Compartments

Biotechnological expression of highly active proteins or small chemical compounds of pharmaceutical relevance is often difficult. Many proteins or molecules of interest (POIs/MOIs) have cytotoxic side effects and interfere with the host’s metabolism. The invention provides a versatile tool - based on a low-temperature inducible protein accumulation system (lt-degron) - and methods to generate so-called ‘phenotypes on demand’ for the production of POIs/MOIs in a spatial and time-dependent manner ensuring proper posttranslational modifications. For the first time, it has been adopted to multicellular organisms like insects and intact plants in vivo. 02.10.2015 | nachricht Read more

Novel Inhibitors of Malassezia pachydermatis

Fungi (yeast) of the genus Malassezia are found on the skin of most humans and animals. In humans this disease is most commonly caused by Malassezia furfur. Infections with this pathogen can result in life-threatening fungemia and other nosocomial infections. Rare cases can be attributed to M. pachydermatis. Novel natural substances are provided, which show highly promising activity against M. pachydermatis. MIC values are comparable to those for terbinafine, which is a synthetic antifungal. 02.10.2015 | nachricht Read more

Therapy of brain tumors by inhibition of nuclear receptor tailles (Tlx)

DKFZ researchers identified nuclear receptor tailles (Tlx) as a valuable drug target for brain tumors especially gliobastomas. In vivo experiments showed almost doubling in survival time of mice harbouring brain tumors by inhibiting the expression of Tlx in tumor cells. In addition a highly significant correlation between expression of Tlx in brain tumor cells and survival of the patient was demonstrated. 30.09.2015 | nachricht Read more

ACIP / Peptide-based Inhibition of Cancer Cachexia

Cachexia related to cancer, occurs in 30-70% of cancer patients and still represents an as-yet non-curable and fatal paraneoplastic syndrome in a variety of tumor entities. The present invention discloses a new method for preventing cancer cachexia based on preventing inhibition of the protein AMPK. 30.09.2015 | nachricht Read more

miRNA-375 and miRNA-141 as non-invasive markers for diagnosis and staging in prostate cancer

6% of all prostate cancer patients die due to their illness. However, 80% of all prostate cancer patients do not need therapy, since their cancers grow slowly. Since the mainly used marker (prostate-specific antigen, PSA) is also elevated in case of inflammatory processes or with benign prostatic hyperplasia, DKFZ inventors analysed serum samples and identified miRNA-375 and miRNA-141 as new biomarkers for high-risk tumors. 30.09.2015 | nachricht Read more

Synthetic lignans targeting cardiovascular diseases

Novel synthetic lignans to affect inflammatory processes related to surgical cardiovascular intervention have been identified. The compounds may have highly beneficial effects for preparation of cardiac by-pass implants as well as for stent conduits. 28.09.2015 | nachricht Read more

Method and apparatus for secure encryption of input and output devices

The novelty of the present invention is to prevent the disturbance of encryption systems and thus lead to better data se-curity. In addition it is aimed at users who have little or no background knowledge. The inventive approach to security is based on the combination of an LCD display and the encryption method "One Time Pad". This results in the advantage that on the user side, the compromised device (PC, smartphone, etc.) only sees the encrypted information itself. At this time the decryption takes place at a sec-ondary LCD display, which is separated with the decoding key from the actual device. Thus, none of the decoded mes-sage transmission takes place on an in-fected device (by spyware or malware), enabling secure transfer of information in spite of monitored devices and commu-nication channels. 28.09.2015 | nachricht Read more

Mercury Quick Test

The invention intends to provide coumarin based nickel-dithiolene complexes, to selectively detect mercury (II) ions in the organism. Based on a Ditholen-ligand, molecules have been developed which can be used to determine the presence of heavy metal ions. Design, manufacture and the properties of a system based on a coumarin nickel dithiolene complex are described, which operates in the wavelength range of ~960 nm with high selectivity and sensitivity for mercury ions even in the presence of other metal ions (eg. Ag+, Al3+, Ca2+, Cu2+, Mg2+, Na+, Sn2+) that can be used in a simple UV / VIS spectroscopy. 28.09.2015 | nachricht Read more

Cardiogenesis inducing synthetic small molecules

Researchers of TUW and MUW have found that cardiomyocyte-like cells may be obtained not only from omnipotent or pluripotent mammalian cells, but also from lineage committed cells, such as skeletal myoblasts when cultured in the presence of substituted pyridine- and pyrimidine-compounds. 28.09.2015 | nachricht Read more

Combined biogas upgrading & power-to-gas energy storage

The novel combined power-to-gas & Biogas upgrading Technology is producing high-purity methane, carbon dioxide and water in a single membrane separation system. 28.09.2015 | nachricht Read more
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Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New Sinumerik features improve productivity and precision

EMO 2015, Hall 3, Booth E06/F03

  • Drive optimization called automatically by the part program boosts productivity
  • Automatically switching the dynamic values to rapid traverse and interpolation...

Im Focus: LZH presents additive manufacturing at the LABVOLUTION

The Laser Zentrum Hannover e.V. (LZH) will present how laser-based technologies can contribute to the laboratory of the future at the LABVOLUTION in Hannover in Hall 9, Stand E67/09, from October 6th to 8th, 2015. As a part of the model lab smartLAB, the LZH is showing how additive manufacturing, better known as 3-D printing, can make experimental setups more flexible.

Twelve partners from science and industry are presenting an intelligent and innovative model lab at the special display smartLAB. A part of this intelligent...

Im Focus: New polymer creates safer fuels

Before embarking on a transcontinental journey, jet airplanes fill up with tens of thousands of gallons of fuel. In the event of a crash, such large quantities of fuel increase the severity of an explosion upon impact.

Researchers at Caltech and JPL have discovered a polymeric fuel additive that can reduce the intensity of postimpact explosions that occur during accidents and...

Im Focus: 3-D printing techniques help surgeons carve new ears

When surgical residents need to practice a complicated procedure to fashion a new ear for children without one, they typically get a bar of soap, carrot or an apple.

To treat children with a missing or under-developed ear, experienced surgeons harvest pieces of rib cartilage from the child and carve them into the framework...

Im Focus: Walk the line

NASA studies physical performance after spaceflight

Walking an obstacle course on Earth is relatively easy. Walking an obstacle course on Earth after being in space for six months is not quite as simple. The...

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