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26 matches found for "ubiquitination"
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The defense strategy of plants
If the mechanism that plants use to defend themselves can be understood, it will be possible to produce plants that are resistant to disease. The Plant Immunity Research Group is also undertaking rese...
Life Sciences |
Read moreStudy reveals how a common virus eludes the immune system
Viruses have numerous tricks for dodging the immune system. In the September 7, 2009 issue of the Journal of Cell Biology, Stagg et al. reveal a key detail in one of these stratagems, identifying a pr...
Studies and Analyses | Read moreProtein can help cells or cause cancer
Xiaoqi Liu, an assistant professor of biochemistry, found that an overabundance of the polo-like kinase 1, or Plk1, molecule during cell growth, as well as a shortage of the p53 molecule, will lead to...
Life Sciences | Read moreShilatifard and colleagues clarify the enzymatic activity of factors involved in childhood leukemia
Many hematological malignancies are associated with a genetic error in which a portion of one chromosome has broken and fused with another chromosome. This inappropriate fusion of chromosomal DNA is r...
Life Sciences | Read moreLipid droplets lead a Spartin existence
Spartin, a protein linked to the neuronal disease Troyer syndrome, was thought to function in endocytosis. In the March 23, 2009 issue of the Journal of Cell Biology (www.jcb.org), Eastman et al. iden...
Life Sciences | Read moreStay of execution
The targeted destruction of specific proteins is an important means of regulation for many cellular pathways. This is typically managed through the process called ubiquitination, in which doomed prote...
Life Sciences | Read morePlant immunity: PUBs are bad for the health
Disease-causing pathogens carry unique molecular motifs that can be recognized by plants. The motifs, known as pathogen-associated molecular patterns or PAMPs, trigger several reactions in the plant w...
Life Sciences | Read moreA cellular task force to safeguard genome stability
A recent study, published in Nature, now sheds light on a complex regulatory system based on sumoylation and ubiquitination, two important regulatory processes involved in DNA repair and, consequently...
Life Sciences | Read morePenn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells
This study shows for the first time how ISG15 slows the spread of Ebola virus budding, an observation that could help explain how ISG15 successfully inhibits other viruses, including HIV-1 and herpes ...
Life Sciences | Read moreWhat's been causing your knee to ache? Smurfs!
A new clinical trial seeks to predict who is most likely to experience osteoarthritis, and to test whether an experimental treatment can prevent it altogether. Physicians are setting their sights on p...
Health and Medicine | Read moreGlue inside the cell: Ubiquitin builds up an immune response
A study headed by the Junior Group of Dr. Daniel Krappmann (GSF - National Research Center for Environment and Health, Institute of Toxicology) in collaboration with Dr. Jürgen Ruland (TU Munich) and ...
Life Sciences | Read moreAn AIDS-related virus reveals more ways to cause cancer
A KSHV protein called latency-associated nuclear antigen, LANA for short, helps the virus hide out from the immune system in infected cells. When LANA takes the place of other proteins that control ce...
Life Sciences | Read moreNovel regulation of the common tumor suppressor PTEN
Researchers led by scientists at Memorial Sloan-Kettering Cancer Center have now identified fundamentally novel regulatory mechanisms of PTEN function. The findings from two related studies are publis...
Health and Medicine | Read moreOne Path – Two Effects: Immune System uses DNA Repair Mechanism to Boost Defence
How does the immune system manage to keep pace with this diversity? For the first time scientists from the GSF – Research Centre for Environment and Health and the Max-Planck-Institute for Biochemist...
Life Sciences | Read moreDrug combo may reduce protease inhibitor-related hardening of the arteries
Writing in the American Journal of Physiology–Cell Physiology, researchers from the University of Kentucky found that when mice were given a nucleoside reverse transcriptase inhibitor (NRTI) and a pro...
Health and Medicine | Read more
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