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Antiviral therapy for the treatment of acute myocarditis
The inflammation of the heart muscle is usually induced by cardiotropic viruses. The invention is based on the findings, that statins can reduce the expression of the coxsackie-adenovirus receptor on ...
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Read moreNo-entry zones for AIDS virus
Like all retroviruses, the AIDS virus (HIV) integrates its DNA into the genome of the infected cell. As integration sites, HIV usually prefers active genes that are transcribed frequently. This is adv...
Life Sciences | Read moreDNA molecules in moss open door to new biotechnology
Researchers from Uppsala University in Sweden have now demonstrated that plasmid-based methods, which had been limited to single-cell organisms such as bacteria and yeasts, can be extended to mosses, ...
Life Sciences | Read moreScientists are first to observe the global motions of an enzyme copying DNA
Perpetuation of DNA mistakes can cause mutations that lead to cancer and other diseases.But before scientists can determine how and when errors are made during DNA replication, they must first...
Life Sciences | Read moreTriple-Combo Drug Shows Promise Against Antiviral-Resistant Swine Flu
In laboratory testing, the triple combination of oseltamivir (Tamiflu), amantadine (Symmetrel) and ribavirin showed a significant capacity to stop flu-virus growth, says Mark Prichard, Ph.D, who serve...
Life Sciences | Read moreScientists Discover Gene that 'Cancer-Proofs' Rodent's Cells
Despite a 30-year lifespan that gives ample time for cells to grow cancerous, a small rodent species called a naked mole rat has never been found with tumors of any kind—and now biologists at the Univ...
Life Sciences | Read moreSingle-stranded DNA-binding protein proven dynamic, critical to DNA repair
Their study, of SSB in the bacterium Escherichia coli, appears today in the journal Nature.Whenever the double helix of DNA unravels, exposing each strand to the harsh environment of the cell,...
Life Sciences | Read moreLoss of Tumor-Suppressor and DNA-Maintenance Proteins Causes Tissue Demise
A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tis...
Studies and Analyses | Read moreResearch shows treating HIV-AIDS with interleukin-2 is ineffective
An international research team has demonstrated that treating HIV-AIDS with interleukin-2 (IL-2) is ineffective. As a result, the researchers recommend that clinical trials on this compound be stopped...
Health and Medicine | Read moreDiscovery of enzyme structure points way to creating less toxic anti-HIV drugs
Their work was published this week in Cell. "Many anti-HIV drugs are designed to stop the process of DNA replication," says Dr. Whitney Yin, assistant professor of chemistry and bioc...
Life Sciences | Read moreScientists decipher the 3-D structure of the human genome
Scientists have deciphered the three-dimensional structure of the human genome, paving the way for new insights into genomic function and expanding our understanding of how cellular DNA folds at scale...
Life Sciences | Read moreDiscovery of regulatory role of key molecule provides further step towards future gene therapy to control disease
The molecule, known as Lysyl-tRNA synthetase (or LysRS in brief) is one of the most ancient molecules in the cell, where it has long been recognized for its contribution in the translation of the info...
Life Sciences | Read moreBrain defect implicated in early schizophrenia
In the first functional magnetic resonance imaging (fMRI) study of its kind, neurologists and psychiatrists at Columbia University have identified an area of the brain involved in the earliest stages ...
Life Sciences | Read moreResearchers Identify Protein–telomere Interactions That Could be Key in Treating Cancer, Other Diseases
Since this RNA also facilitates the formation of DNA at telomeres—a process that can protect aging cells and destabilize tumor cells—manipulating its expression may be useful in treating cancer and ot...
Life Sciences | Read moreChemotherapy Resistance: Checkpoint Protein Provides Armor Against Cancer Drugs
Their findings, published in the Aug. 28 issue of Molecular Cell, help explain how the checkpoint exit is delayed in some cancer cells, helping them to recover and resume dividing after treatment with...
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