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How Cells Tolerate DNA Damage – MDC Researchers Identify Start Signal for Cell Survival Program
Dr. Michael Stilmann, Dr. Michael Hinz and Professor Claus Scheidereit have shown that the protein PARP-1, which detects DNA damage within seconds, activates the transcription factor NF-kappaB, a well...
Life Sciences |
Read moreResearch Reveals Lipid’s Unexpected Role in Triggering Death of Brain Cells
The work provides the first evidence that a lipid can initiate the suicidal, or apoptotic, response in cells. The findings involve a lipid called GM1-ganglioside. Lipids are fat-like molecules. GM1 bu...
Life Sciences | Read moreResearch reveals lipids' unexpected role in triggering death of brain cells
The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St. Jude Child...
Life Sciences | Read moreDrug shrinks lung cancer tumors in mice
The authors of the research, from Imperial College London, are now planning to take the drug into clinical trials, to establish whether it could offer hope to patients with an inoperable form of lung ...
Health and Medicine | Read moreNow hear this: Mouse study sheds light on hearing loss in older adults
"Age-related hearing loss is a very common symptom of aging in humans, and also is universal among mammal species, and it's one of the earliest detectable sensory changes in aging," say...
Health and Medicine | Read moreMultiple sclerosis: T cells as serial killers
This is what regularly happens in the targeted immunological attack on the myelin sheaths of the nerve cells, as shown experimentally for the first time by researchers from Würzburg and Zürich....
Life Sciences | Read moreExperimental drug lets B cells live and lymphoma cells die
To function normally, the cells that make up bodily tissues must "decide" when to divide and multiply (proliferate) and when to die. Cell death restricts the human cell population as a count...
Life Sciences | Read moreHow Proteins Talk to Each Other
Investigators at Burnham Institute for Medical Research (Burnham) have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins). Using ...
Life Sciences | Read moreApoptosis-Inducing Metal-Containing-Nucleoside-Analogues
Nucleoside analogues are a class of compounds that trigger programmed cell death (apoptosis). This happens as they incorporate into cellular DNA where they inhibit DNA synthesis. The efficiency of ind...
Technology Offerings | Read moreGreen tea component may help preserve stored platelets, tissues
Published in the current double issue of Cell Transplantation (18:5/6), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct, devoted to organ preservation and transplantation ...
Life Sciences | Read moreStudy Supports DNA Repair-blocker Research in Cancer Therapy
The findings being reported in the Aug. 14 issue of Molecular Cell help explain the promising results being seen in clinical trials of compounds that force cancer cells with genetic damage to self-des...
Life Sciences | Read moreHepatitis C virus channels efforts into cell survival
A study published in the Proceedings of the National Academy of Sciences (PNAS) shows that the virus blocks the actions of a specific ion channel in the cell membrane that would usually trigger apopto...
Studies and Analyses | Read moreDiscovery may lead to powerful new therapy for asthma
University of Texas Medical Branch at Galveston researchers have found that a single enzyme is apparently critical to most allergen-provoked asthma attacks — and that activity of the enzyme, known as ...
Health and Medicine | Read moreSTAT3 Gene Regulates Cancer Stem Cells in Brain Cancer
Cancer stem cells have many characteristics of stem cells and are thought to be the cells that drive tumor formation. The researchers report that STAT3 could become a target for cancer therapy, specif...
Life Sciences | Read moreLife and death in the living brain
Now, for the first time, University of Washington neurobiologists have interrupted this natural "annual remodeling" of the brain and have shown that there is a direct link between the death ...
Health and Medicine | Read more
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