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7 matches found for "Sumoylation"

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Protein can help cells or cause cancer

Xiaoqi Liu, an assistant professor of biochemistry, found that an overabundance of the polo-like kinase 1, or Plk1, molecule during cell growth, as well as a shortage of the p53 molecule, will lead to...

Life Sciences |

The difference between eye cells is…sumo?

Researchers at the Johns Hopkins University School of Medicine and Washington University School of Medicine have identified a key to eye development — a protein that regulates how the light-sensing ne...

Life Sciences |

A cellular task force to safeguard genome stability

A recent study, published in Nature, now sheds light on a complex regulatory system based on sumoylation and ubiquitination, two important regulatory processes involved in DNA repair and, consequently...

Life Sciences |

Gene offers new lead in cleft lip and palate research

With several genes already implicated in causing cleft lip and palate, the authors note their addition to the list comes with a unique biological twist. The SUMO1 gene encodes a small protein that is ...

Life Sciences |

Homeoprotein DNA-binding specificity

In marked contrast to their precise target recognition in vivo, in vitro, homeoproteins bind DNA quite promiscuously. In their upcoming paper, Dr. Abate-Shen and colleagues demonstrate that the PIAS1 ...

Life Sciences |

Researchers find molecule that may hold key to learning and memory

Independent research teams from Harvard Medical School and Children’s Hospital Boston have identified a master protein that sheds light on one of neurobiology’s biggest mysteries--how neur...

Life Sciences |

Protein tags regulate key ion channel

Newly recognized process solves 50-year-old mystery Researchers at the University of Chicago have found that a recently discovered biological process known as sumoylation -- u...

Life Sciences |

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