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New combination therapy could deliver powerful punch to breast cancer
While they are powerful killers of some breast cancer cells, new drugs called histone deacetylase inhibitors, or HDAC inhibitors, also increase self-digestion, or autophagy, in surviving, mega-stresse...
Health and Medicine |
Read moreUnraveling the mechanisms behind organ regeneration in zebrafish
Now researchers at the Salk Institute for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns l...
Life Sciences | Read moreWhat Drives Our Genes? Researchers Map the First Complete Human Epigenome
Now, researchers at the Salk Institute provide the first detailed map of the human epigenome, the layer of genetic control beyond the regulation inherent in the sequence of the genes themselves....
Life Sciences | Read moreResearcher solves mystery about proteins that package the genome
A Florida State University College of Medicine researcher has solved a century-old mystery about proteins that play a vital role in the transfer of the human genetic code from one cell to another. The...
Life Sciences | Read moreMechanism for potential Friedreich's ataxia drug uncovered
Using clever chemistry, a Scripps Research team has pinpointed the enzyme target of a drug group that stops the progression of the devastating disease Friedreich's ataxia in mice and may do the s...
Life Sciences | Read moreLipid involved with gene regulation uncovered
Virginia Commonwealth University School of Medicine researchers have discovered a new role for the bioactive lipid messenger, sphingosine-1-phosphate, or S1P, that is abundant in our blood – a finding...
Life Sciences | Read moreAurora B answers an XIST-ential question
Early in development, mammalian female cells counteract their double dose of X chromosomes by coating one of them with a large RNA named XIST. The RNA binds to the same X chromosome from which it is t...
Life Sciences | Read moreProtein plays unexpected role protecting chromosome tips
A protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destru...
Life Sciences | Read moreRaising the alarm when DNA goes bad
Our genome is constantly under attack from things like UV light and toxins, which can damage or even break DNA strands and ultimately lead to cancer and other diseases.Scientists have known fo...
Life Sciences | Read moreScientists discover key event in prostate cancer progression
The onset of hormone-independent growth marks an advanced and currently incurable stage of prostate cancer. The study, published in the July 24, 2009, issue of the journal Cell, focuses on and...
Health and Medicine | Read moreThe ultimate brow lift: HDAC8 in the epigenetic control of skull morhpgenesis
HDAC8 overexpression is associated with a poor prognosis in human neuroblastoma patients. "As there are many different isoforms of histone deacetylases, it is crucial to understand the specific f...
Life Sciences | Read morePushmi-pullyu of B-Cell Development Discovered
James Hagman, PhD, Professor of Immunology at National Jewish Health and his colleagues have identified two "molecular motors" that work in opposing directions to control the development of ...
Life Sciences | Read moreUniversitat Autonoma de Barcelona researchers first to clone mice in Spain
Researchers at the Department of Cell Biology, Physiology and Immunology at Universitat Autònoma de Barcelona (UAB) are the first to have cloned mice in Spain.Cloe, Cleo and Clona are three fe...
Life Sciences | Read moreResearch Team Finds Key Target of Aging Regulator
Scientists have long known that a class of proteins called sirtuins promotes fitness and longevity in most organisms ranging from single-celled yeast to mammals. At the cellular level, sirtuins protec...
Life Sciences | Read moreGood fences make good neighbors
Breaking down just a few of the molecular fences that separate them blurs the lines and leads to the inactivation of at least two tumor suppressor genes, according to researchers at the Salk Institute...
Life Sciences | Read more
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