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Nanoparticles Found in Common Household Items Caused Genetic Damage in Mice
The TiO2 nanoparticles induced single- and double-strand DNA breaks and also caused chromosomal damage as well as inflammation, all of which increase the risk for cancer. The UCLA study is the first t...
Life Sciences |
Read moreHow Cells Tolerate DNA Damage – MDC Researchers Identify Start Signal for Cell Survival Program
Dr. Michael Stilmann, Dr. Michael Hinz and Professor Claus Scheidereit have shown that the protein PARP-1, which detects DNA damage within seconds, activates the transcription factor NF-kappaB, a well...
Life Sciences | Read moreResearchers Use Drug-radiation Combo to Eradicate Lung Cancer
In a study appearing in the October issue of Cancer Research, UT Southwestern researchers found that if they administered BEZ235 before they damaged the DNA of tumor cells with otherwise nontoxic radi...
Health and Medicine | Read moreSingle-stranded DNA-binding protein proven dynamic, critical to DNA repair
Their study, of SSB in the bacterium Escherichia coli, appears today in the journal Nature.Whenever the double helix of DNA unravels, exposing each strand to the harsh environment of the cell,...
Life Sciences | Read moreLoss of Tumor-Suppressor and DNA-Maintenance Proteins Causes Tissue Demise
A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tis...
Studies and Analyses | Read moreResearchers Identify Workings of L-Form Bacteria
L-form bacteria, which were first discovered in the 1930s, are morphological variants of classical bacteria that lack a cell wall. Under specialized growth conditions L-form bacteria are capable of fo...
Life Sciences | Read moreResearcher solves mystery about proteins that package the genome
A Florida State University College of Medicine researcher has solved a century-old mystery about proteins that play a vital role in the transfer of the human genetic code from one cell to another. The...
Life Sciences | Read moreChemotherapy Resistance: Checkpoint Protein Provides Armor Against Cancer Drugs
Their findings, published in the Aug. 28 issue of Molecular Cell, help explain how the checkpoint exit is delayed in some cancer cells, helping them to recover and resume dividing after treatment with...
Life Sciences | Read moreStudy Supports DNA Repair-blocker Research in Cancer Therapy
The findings being reported in the Aug. 14 issue of Molecular Cell help explain the promising results being seen in clinical trials of compounds that force cancer cells with genetic damage to self-des...
Life Sciences | Read moreProtein plays unexpected role protecting chromosome tips
A protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destru...
Life Sciences | Read moreFrom cell division to ageing - scientists locate main cell switches
Scientists from the Max Planck Institute of Biochemistry and the University of Copenhagen have now been able to prove that the reversible attachment of acetyl groups influences virtually all functions...
Life Sciences | Read moreRaising the alarm when DNA goes bad
Our genome is constantly under attack from things like UV light and toxins, which can damage or even break DNA strands and ultimately lead to cancer and other diseases.Scientists have known fo...
Life Sciences | Read moreThe violent youth of solar proxies steer course of genesis of life
New research shows that compared to middle-aged stars like the Sun, newly formed stars spin faster generating strong magnetic fields that result in emission of more intense levels of X-rays, ultraviol...
Physics and Astronomy | Read moreTumor mutations can predict chemo success
New work by MIT cancer biologists shows that the interplay between two key genes that are often defective in tumors determines how cancer cells respond to chemotherapy.The findings should have...
Life Sciences | Read moreProtein complex key in avoiding DNA repair mistakes, cancer
As the body creates antibodies to fight invaders, a three-protein DNA repair complex called MRN is crucial for a normal gene-shuffling process to proceed properly, University of Michigan research show...
Life Sciences | Read more
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