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551 matches found for "CASCADE"

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Computational microscope peers into the working ribosome

The first study, in Proceedings of the National Academy of Sciences, concerns the intimate signaling between the ribosome and an elongation factor (EF-Tu) that is essential to the successful assembly ...

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How Cells Tolerate DNA Damage – MDC Researchers Identify Start Signal for Cell Survival Program

Dr. Michael Stilmann, Dr. Michael Hinz and Professor Claus Scheidereit have shown that the protein PARP-1, which detects DNA damage within seconds, activates the transcription factor NF-kappaB, a well...

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Research Reveals Lipid’s Unexpected Role in Triggering Death of Brain Cells

The work provides the first evidence that a lipid can initiate the suicidal, or apoptotic, response in cells. The findings involve a lipid called GM1-ganglioside. Lipids are fat-like molecules. GM1 bu...

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Research reveals lipids' unexpected role in triggering death of brain cells

The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St. Jude Child...

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Penn Study Provides First Clear Idea of How Rare Bone Disease Progresses

An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibr...

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In the war between the sexes, the one with the closest fungal relationship wins

The war between the sexes has been fought on many fronts throughout time—from humans to birds to insects, the animal kingdom is replete with species involved in their own skirmishes. A recent ...

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Researcher discovers key to vital DNA, protein interaction

Adam Bogdanove, associate professor in plant pathology, was researching the molecular basis of bacterial diseases of rice when he and Matthew Moscou, a student in the bioinformatics and computation bi...

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Interactions with aerosols boost warming potential of some gases

Yet the complexity of nature -- and the models used to quantify it -- continues to serve up surprises. The most recent? Certain gases that cause warming are so closely linked with the production of ae...

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Satellite data look behind the scenes of deadly earthquake

"One of the very fundamental issues for understanding an earthquake is to know how the rupture is distributed on the fault plane, which is directly related to the amount of ground shaking and the...

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Field Guide Showcases Pacific Northwest Geology and Terroir

Use this guide to visit and learn the latest geoscience details on Mount Hood, Newberry Volcano, and Mount St. Helens; the Channeled Scabland of Columbia valley; the Salmon and Columbia Rivers; the Kl...

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Panama butterfly migrations linked to El Niño, climate change

"Our long-term study shows that El Niño, a global climate pattern, drives Sulfur butterfly migrations," said Robert Srygley, former Smithsonian post doctoral fellow who is now a research eco...

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Forecasting solar-energy harvests

Most life on earth depends on the sun to provide the energy needed to sustain its function. For more than a billion years, photosynthesis—a mechanism that has evolved to perfection—has allowed plants ...

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CHIP as a new target for thetreatment and prevention of muscular dystrophies

<p> Muscular dystrophies are a heterogenous group of inherited single-gene disorders, characterized clinically by progressive muscle weakness and wasting. In many cases the molecular basis of a ...

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Experimental drug lets B cells live and lymphoma cells die

To function normally, the cells that make up bodily tissues must "decide" when to divide and multiply (proliferate) and when to die. Cell death restricts the human cell population as a count...

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To regenerate muscle, cellular garbage men must become builders

For scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, what seemed like a disappointing result turned out to be an important discovery. Their findings, publ...

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