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Biodegradable colloidal particles for inhalative administration

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13.12.2006

Inhalative administration is an important method of application for medications and active ingredients for the treatment of pulmonary diseases.<br><br> Now nanoparticular transport vehicles are available, which absorb active ingredients and release them at the desired location, i.e. the lungs. In particular, these are biodegradable particles, which are composed of a biologically degradable amphiphilic comb polymer, which is based on a polyol backbone with positively charged side chains. The biodegradable particles are suitable for simple and patient-friendly application, in particular for inhalative administration of pharmaceutical agents for the treatment of diseases in humans and higher mammals.<br><br> The particles remain stable during the process of aerosol production, i.e. through nebulisation and release the agents continuously after deposition in the lungs, whereby a constant drug level is ensured. It is of particular advantage that, due to this targeted administration of pharmaceutical agents, the number of necessary inhalations can be considerably reduced.

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