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RNA aptamers in sepsis therapy

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13.12.2006

Aptamers are special nucleic acids with structural characteristics which allow them to bind to a specific protein as a target molecule. Selected RNA aptamers with a characteristic lead structure already exist, which bind specifically to the murine, lipopolysaccharide-binding protein (mLBP). This protein LBP plays a key role during septic shock and is linked to the LPS-induced signalling cascade. The selected RNA aptamers constitute valuable molecular tools in sepsis research and fulfil the preconditions for the development of new diagnostic and therapeutic medicines for the treatment of septic shock.

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