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Novel Pharmaceutical Compounds against Malaria Disease

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07.02.2007

Several isoquinoline alkaloids with interesting, pharmaceutically useful properties have recently been isolated from marine as well as terrestrial organisms. They served as models for 3,3-dimethyl-8-oxo-di-(or: tetra-)hydroisoquinolines, a compound class which is easily accessible by total synthesis and for which pronounced activities against protozoae have been found in cell vitality assays.

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