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Monoclonal antibody: Rat anti-murine Chemokine Receptor 9 (Cdw199)

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20.09.2007

Scientists at the Georg-August-University produced a monoclonal antibody which recognises murine CD199, which is commonly known as chemokine receptor 9 (CCR9). The protein CCR9 is a member of the beta chemokine receptor family. It is a seven transmembrane protein similar to G protein coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this receptor is differentially expressed by T-lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitement and development that they may permit functional specialization of immune responses in different segment of the gastrointestinal tract, where they are not in other tissues. When tested against 10 different viral strains, CCR9 acted as a co-receptor for only one a single primary T-cell-tropic strain, HIV-1(UG-21). This lack of activity is interesting, given that CCR9 expresses a tyrosine rich amino-terminal element, reminiscent of CCR5, that has been postulated to be important for HIV co-receptor function.

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