Home Special Topics Technology Offerings Content

Microginin Synthetase - Gene Cluster and Application in Biocombinatorics

next article

19.10.2012

<strong>Technology</strong><br> The complete DNA sequence of the gene cluster coding for the microginin synthetase of the cyanobacterium Microcystis aeruginosa has been identified and sequenced for the first time. The microginin synthetase is a large multi-enzyme complex which catalyzes the microginin, a small linear lipopeptide belonging to the group of non-ribosomal synthesized peptides. <br><br> Microginins are synthesized by various species of cyanobacteria (“blue-green algae”) in diverse structure variants. Mircroginins represent an interesting group of unusual peptides in view of medical application as they are known to have inhibitory effects on the Angiotensin-Converting- Enzyme (ACE). Thus, microginins are potential ACE-inhibitors and represent important drug candidates to treat hypertension and associated diseases such as chronic heart failure and diabetic nephropathy.<br><br> The new identified DNA-sequence of the microginin synthetase gene cluster can be used to identify homologue gene cluster in other cyanobacteria spe-cies and as a matter of fact for the detection of new microginin variants or microginin-like structures. Further on, novel microginin variants can be gen-erated by gene biocombinatoric experiments (gene shuffling) with the objec-tive to optimize the ACE-inhibitory effect. <br><br> <b>Benefits:</b><ul> <li>10-30 % therapies of patients treated with currently available ACE-inhibitors are ineffective -> Novel or improved ACE-inhibitors to treat hypertension are needed</li> <li>Microginins are non-toxic and show ACE-inhibitory effects</li> <li>Easy and effective method to identify microginin-producing strains of cyanobacteria</li> <li>Easy method to generate novel non-natural microginins or microginin-like structures optimizing the ACE-inhibitory effect</li> </ul> <p><strong>IP Rights</strong><br> Patent granted in US, CH, DE, FR, GB, IE, LU, SE <br><br> <strong>Patent Owner</strong><br> Humboldt-Universität zu Berlin

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Contact
Dr. Dirk Dantz

As Germany's association of technology- and patenttransfer agencies TechnologieAllianz e.V. is offering businesses access to the entire range of innovative research results of almost all German universities and numerous non-university research institutions. More than 2000 technology offers of 14 branches are beeing made accessable to businesses in order to assure your advance on the market. At www.technologieallianz.de a free, fast and non-bureaucratic access to all further offers of the German research landscape is offered to our members aiming to sucessfully transfer technologies.

info@technologieallianz.de | Source: TechnologieAllianz e.V.
Further information: www.technologieallianz.de/angebote.php?sort=sag&id=2860&lang=en
www.technologieallianz.de

next article