Bone erosion prognosis in rheumatoid arthritis. Interleukin-22 (IL-22) has been identified as a prognostic marker for bone erosion associated with rheumatoid arthritis and as a diagnostic marker for the progression of the disease. Generally, the concentration of IL-22 can be determined by detecting the IL-22 protein but also by detecting the amount of IL-22 mRNA transcripts (e.g. by detecting hybridization to a gene transcript of the IL-22 gene or by PCR methods, such as Real-time PCR), for instance in the tissue.
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