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Tumour therapy with more effective chlorine compounds

16.04.2014

Photodynamic tumour therapy (PDT) is a promising minimal-invasive method in the treatment of cancer. PDT is based on a method for the treatment of cancer with light in combination with a so-called  photosensitizer. In contrast to traditional photosensitisers, the chlorine compounds developed at and patented by the University of Bremen show amphiphilic (both hydrophilic and lipophilic) properties. The combination of lipophilic and non-ionic hydrophilic structure parts enables both good transport properties via the bloodstream and increased accumulation in the tumour tissue. Due to the synthesis of the novel photosenitisers, exceedingly suitable candidates as active substances have been formed with the potential to improve the photodynamic therapy and its effectiveness. Moreover, the chemical process for the production of these compounds has been improved, enabling for the first time the clinical use of the structurally challenging photosensitisers in an economic way. Initial experiments to verify the effectiveness have been carried out in vitro. The next step will be the verification in the animal model. We are looking for partner companies interested in the further development of the active substance using the patent.

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