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Trinukleotidsynthos

20.01.2010
Im letzten Jahrzehnt hat das Interesse an effizienten Methoden für die gezielte Mutagenese stark zugenommen. Dabei stehen die Funktionsoptimierung von Proteinen und Peptiden sowie das Design neuer Enzyme im Vordergrund. Enzyme führen in unterschiedlichen industriellen Produktionsprozessen die Synthese von hochreinen chemischen Substanzen durch. Ihre Leistungsfähigkeit ist im Bezug auf die Effizienz besonders hoch und lässt sich mit Hilfe der Modifikation des genetischen Codes noch entscheidend verbessern.

Durch die Verwendung von synthetisch hergestellten Oligonukleotiden werden an ausgewählten Orten der Proteinsequenz Variationen der 20 Aminosäuren generiert. Werden üblicherweise gemischte Oligonukleotide durch statistische Kopplung einer Nukleotidmischung in jedem Zyklus der automatisierten Festphasensynthese erzeugt, so ist es unmöglich, die Einbringung unerwünschter Aminosäuren oder gar die Erzeugung von Stop-Codons zu vermeiden. Trinukleotid-Synthons werden als besser geeignete Synthesebausteine für die Generierung von kontrolliert gemischten Oligonukleotiden angesehen.

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