<br> Based on the results of early clinical trials, oncolytic virotherapy holds promise as a safe and effective treatment strategy for advanced HCC. It has been demonstrated that recombinant vesicular stomatitis virus (VSV) vectors are particularly attractive oncolytic agents for the treatment of HCC, resulting in significant tumor responses and subsequent prolongation of survival. <br> Over the last 25 years, much progress has been made in understanding the mechanism of liver fibrogenesis, and as a result, it is now believed that fibrosis and cirrhosis are reversible processes. Despite this growing body of evidence, the clinical management of cirrhosis has fallen behind, and the success of available therapies has yet to be demonstrated. The challenge for a successful and safe antifibrotic therapy is specific targeting of the responsible cell types involved in fibrotic progression, without the introduction of collateral toxicities. In a preclinical rodent model of HCC with underlying fibrosis it could be shown that VSV administered by hepatic arterial infusion does not only maintain its ability to efficiently and selectively kill tumor cells, but it also possesses antifibrotic properties which provides the unique benefit in concomitant reversal of fibrotic progression with a single agent. Therefore, this innovation represents a significant therapeutic advantage over the current state of the art.
firstname.lastname@example.org | TechnologieAllianz e.V.
Dosing system of bulk material (granulates) for expansion injection molding
19.01.2017 | TechnologieAllianz e.V.
Efficient method for Chain Multiplication of unsaturated fatty acids - synthesis of ultra long-chain compounds
18.01.2017 | TechnologieAllianz e.V.
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences