<br> Based on the results of early clinical trials, oncolytic virotherapy holds promise as a safe and effective treatment strategy for advanced HCC. It has been demonstrated that recombinant vesicular stomatitis virus (VSV) vectors are particularly attractive oncolytic agents for the treatment of HCC, resulting in significant tumor responses and subsequent prolongation of survival. <br> Over the last 25 years, much progress has been made in understanding the mechanism of liver fibrogenesis, and as a result, it is now believed that fibrosis and cirrhosis are reversible processes. Despite this growing body of evidence, the clinical management of cirrhosis has fallen behind, and the success of available therapies has yet to be demonstrated. The challenge for a successful and safe antifibrotic therapy is specific targeting of the responsible cell types involved in fibrotic progression, without the introduction of collateral toxicities. In a preclinical rodent model of HCC with underlying fibrosis it could be shown that VSV administered by hepatic arterial infusion does not only maintain its ability to efficiently and selectively kill tumor cells, but it also possesses antifibrotic properties which provides the unique benefit in concomitant reversal of fibrotic progression with a single agent. Therefore, this innovation represents a significant therapeutic advantage over the current state of the art.
firstname.lastname@example.org | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.
Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
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