Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

TAXA-FIX - Purification of taxanes by means of CPC or CCC

16.12.2011
TheTAXA-FIX invention relates to a process for separating and purifying taxanes using liquid-liquid partition chromatography (e.g. FCPC). In this case the taxanes, which are produced by fermentative action, for example, can be separated chromato-graphically from the supernatant of a cell suspension culture either directly or after a preliminary separation with solvent changeover (e.g. adsorption). The high productivity of partition chromatography in association with its good selectivity results in fewer process steps and a lower solvent consumption in comparison to existing processes. The overall process achieves higher yields and is therefore clearly more cost-effective than conventional processes.

Commercial Application: The invention relates to a process for the large-scale produc-tion of taxanes, in particular Baccatin III and 10-DAB III. These taxanes that occur naturally in the bark of the Pacific or Euro-pean yew tree are, inter alia, precursors of the cytostatic sub-stances Paclitaxel and Docetaxel, which have been used as anticancer drugs under the brand names Taxol® and Taxotere® since the beginning of the 90s. Because of the unique mecha-nism of action, there is a high demand for these substances on the world market. With a turnover of more than 4 billion dollars, taxanes were the best-selling cytostatics worldwide in 2007. Nevertheless, treatments are very expensive because of the market prices for Paclitaxel and Docetaxel or their precursors. There is therefore a requirement for a more effective downstream process for purifying these substances.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 10

Contact
Dipl.-Ing. Alfred Schillert

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2556&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Zap! Graphene is bad news for bacteria

23.05.2017 | Life Sciences

Medical gamma-ray camera is now palm-sized

23.05.2017 | Medical Engineering

Discovery of an alga's 'dictionary of genes' could lead to advances in biofuels, medicine

23.05.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>