Commercial Application: The invention relates to a process for the large-scale produc-tion of taxanes, in particular Baccatin III and 10-DAB III. These taxanes that occur naturally in the bark of the Pacific or Euro-pean yew tree are, inter alia, precursors of the cytostatic sub-stances Paclitaxel and Docetaxel, which have been used as anticancer drugs under the brand names Taxol® and Taxotere® since the beginning of the 90s. Because of the unique mecha-nism of action, there is a high demand for these substances on the world market. With a turnover of more than 4 billion dollars, taxanes were the best-selling cytostatics worldwide in 2007. Nevertheless, treatments are very expensive because of the market prices for Paclitaxel and Docetaxel or their precursors. There is therefore a requirement for a more effective downstream process for purifying these substances.
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Dipl.-Ing. Alfred Schillert
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