Synthetic multifunctional proteins useful for vaccination against tumor antigens
Despite enormous efforts in research, curing cancer still remains a major challenge in modern medicine. It has been proposed that cytotoxic T cells recognizing antigens that are only expressed in tumor cells could be of great value in cancer therapy, as they could contribute to the elimination of cancer cells. The main problem faced so far by this approach has been that immune responses obtained with immunogens made of current tumor-derived antigens were insufficient. Here, we intro-duce a new method that uses multifunctional fusion proteins consisting of one or more tumor antigen domain(s), an immune stimulatory domain and a carrier domain mediating assembly into virus-like particles. The resulting particles are highly immunogenic and induce strong cellular immune responses against tumor cells.
Further Information: PDF
Deutsches Krebsforschungszentrum DKFZ
Phone: +49-6221-42 2955
Contact
Dr. Ruth Herzog
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Silicon Carbide Innovation Alliance to drive industrial-scale semiconductor work
Known for its ability to withstand extreme environments and high voltages, silicon carbide (SiC) is a semiconducting material made up of silicon and carbon atoms arranged into crystals that is…
New SPECT/CT technique shows impressive biomarker identification
…offers increased access for prostate cancer patients. A novel SPECT/CT acquisition method can accurately detect radiopharmaceutical biodistribution in a convenient manner for prostate cancer patients, opening the door for more…
How 3D printers can give robots a soft touch
Soft skin coverings and touch sensors have emerged as a promising feature for robots that are both safer and more intuitive for human interaction, but they are expensive and difficult…
