Iron oxide nanoparticles are described for usage in therapeutic hyperthermia as well as for magnetic particle imaging and spectroscopy (MPI, MPS). Application of those particles in hyperthermia therapy (injection into tumor cells and exposure to an alternating magnetic field to damage tumor cells) is well known whereas MPI is a quite new tomographic imaging technique based on the non-linear magnetization behavior of superparamagnetic iron oxide nanoparticles (SPIOs). So far it is clear that MPI will have potential for many different diagnostic applications but it is still lacking appropriate SPIO tracers to achieve and guarantee the best possible image quality.<br><br> <strong>Technology</strong><br> The newly synthesized SPIO tracer for MPI according to this invention are assumed to have properties that guarantee a very well image quality and moreover enable them to be used in various biological systems and therewith in preclinical and clinical development. The SPIOs are provided as magnetic particle dispersion comprising single- or multi-core nanoparticles of iron oxides like magnetite and/or maghemite. For in vivo applications and stabilization the particles are coated with a biocompatible shell, preferably a polymer. In first experiments the dispersions showed an improved nonlinear magnetization behavior and a distinctive overtone structure that are clearly superior to SPIOs known in the state of the art so far. Moreover these SPIOs show improved heating properties when subjected to an alternating magnetic field. The proposed SPIO dispersions are suitable for applications in MPI, MRS, MRI, hyperthermia therapy, cell tracking and diagnosis of tumors, cardiovascular-, bone marrow-, lymph node- or liver diseases. <br> <br>
firstname.lastname@example.org | TechnologieAllianz e.V.
Device and Method for Improving a P ersons Mobility
12.02.2016 | TechnologieAllianz e.V.
4D-PET- and SPECT-Phantom model compounds with anatomic realistic contours
11.02.2016 | TechnologieAllianz e.V.
Today, plants and microorganisms are heavily used for the production of medicinal products. The production of biopharmaceuticals in plants, also referred to as “Molecular Pharming”, represents a continuously growing field of plant biotechnology. Preferred host organisms include yeast and crop plants, such as maize and potato – plants with high demands. With the help of a special algal strain, the research team of Prof. Ralph Bock at the Max Planck Institute of Molecular Plant Physiology in Potsdam strives to develop a more efficient and resource-saving system for the production of medicines and vaccines. They tested its practicality by synthesizing a component of a potential AIDS vaccine.
The use of plants and microorganisms to produce pharmaceuticals is nothing new. In 1982, bacteria were genetically modified to produce human insulin, a drug...
Atomic clock experts from the Physikalisch-Technische Bundesanstalt (PTB) are the first research group in the world to have built an optical single-ion clock which attains an accuracy which had only been predicted theoretically so far. Their optical ytterbium clock achieved a relative systematic measurement uncertainty of 3 E-18. The results have been published in the current issue of the scientific journal "Physical Review Letters".
Atomic clock experts from the Physikalisch-Technische Bundesanstalt (PTB) are the first research group in the world to have built an optical single-ion clock...
The University of Würzburg has two new space projects in the pipeline which are concerned with the observation of planets and autonomous fault correction aboard satellites. The German Federal Ministry of Economic Affairs and Energy funds the projects with around 1.6 million euros.
Detecting tornadoes that sweep across Mars. Discovering meteors that fall to Earth. Investigating strange lightning that flashes from Earth's atmosphere into...
Physicists from Saarland University and the ESPCI in Paris have shown how liquids on solid surfaces can be made to slide over the surface a bit like a bobsleigh on ice. The key is to apply a coating at the boundary between the liquid and the surface that induces the liquid to slip. This results in an increase in the average flow velocity of the liquid and its throughput. This was demonstrated by studying the behaviour of droplets on surfaces with different coatings as they evolved into the equilibrium state. The results could prove useful in optimizing industrial processes, such as the extrusion of plastics.
The study has been published in the respected academic journal PNAS (Proceedings of the National Academy of Sciences of the United States of America).
Exceeding critical temperature limits in the Southern Ocean may cause the collapse of ice sheets and a sharp rise in sea levels
A future warming of the Southern Ocean caused by rising greenhouse gas concentrations in the atmosphere may severely disrupt the stability of the West...
12.02.2016 | Event News
09.02.2016 | Event News
02.02.2016 | Event News
12.02.2016 | Physics and Astronomy
12.02.2016 | Life Sciences
12.02.2016 | Medical Engineering