Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Superparamagnetic Iron Oxide Nanoparticles

14.11.2012
<strong>Background</strong><br>

Iron oxide nanoparticles are described for usage in therapeutic hyperthermia as well as for magnetic particle imaging and spectroscopy (MPI, MPS). Application of those particles in hyperthermia therapy (injection into tumor cells and exposure to an alternating magnetic field to damage tumor cells) is well known whereas MPI is a quite new tomographic imaging technique based on the non-linear magnetization behavior of superparamagnetic iron oxide nanoparticles (SPIOs). So far it is clear that MPI will have potential for many different diagnostic applications but it is still lacking appropriate SPIO tracers to achieve and guarantee the best possible image quality.<br><br> <strong>Technology</strong><br> The newly synthesized SPIO tracer for MPI according to this invention are assumed to have properties that guarantee a very well image quality and moreover enable them to be used in various biological systems and therewith in preclinical and clinical development. The SPIOs are provided as magnetic particle dispersion comprising single- or multi-core nanoparticles of iron oxides like magnetite and/or maghemite. For in vivo applications and stabilization the particles are coated with a biocompatible shell, preferably a polymer. In first experiments the dispersions showed an improved nonlinear magnetization behavior and a distinctive overtone structure that are clearly superior to SPIOs known in the state of the art so far. Moreover these SPIOs show improved heating properties when subjected to an alternating magnetic field. The proposed SPIO dispersions are suitable for applications in MPI, MRS, MRI, hyperthermia therapy, cell tracking and diagnosis of tumors, cardiovascular-, bone marrow-, lymph node- or liver diseases. <br> <br>

<strong>Benefits</strong><br> <ul> <li>Enhanced nonlinear magnetization behavior</li> <li>Distinctive overtone structure</li> <li>Improved heating properties</li> <li>Well-functioning contrast agent for MPI </li> </ul><br> <strong>IP Rights</strong><br> EP and US patent application ( Feb. 2012) <br> <br> <strong>Origin</strong><br> Charité-Universitätsmedizin Berlin<br> Physikalisch-Technische Bundesanstalt </p>

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Contact
Dr. Dirk Dantz

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2976&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht Low-vibration sample holder for cryo fluorescence microscopic applications
27.03.2015 | TechnologieAllianz e.V.

nachricht Variable number of threads in braiding machines
16.03.2015 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Experiment Provides the Best Look Yet at 'Warm Dense Matter' at Cores of Giant Planets

In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...

Im Focus: Energy-autonomous and wireless monitoring protects marine gearboxes

The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.

As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...

Im Focus: 3-D satellite, GPS earthquake maps isolate impacts in real time

Method produced by UI researcher could improve reaction time to deadly, expensive quakes

When an earthquake hits, the faster first responders can get to an impacted area, the more likely infrastructure--and lives--can be saved.

Im Focus: Atlantic Ocean overturning found to slow down already today

The Atlantic overturning is one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards. Also known as the Gulf Stream system, it is responsible for the mild climate in northwestern Europe. 

Scientists now found evidence for a slowdown of the overturning – multiple lines of observation suggest that in recent decades, the current system has been...

Im Focus: Robot inspects concrete garage floors and bridge roadways for damage

Because they are regularly subjected to heavy vehicle traffic, emissions, moisture and salt, above- and underground parking garages, as well as bridges, frequently experience large areas of corrosion. Most inspection systems to date have only been capable of inspecting smaller surface areas.

From April 13 to April 17 at the Hannover Messe (hall 2, exhibit booth C16), engineers from the Fraunhofer Institute for Nondestructive Testing IZFP will be...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Conference On Regenerative Medicine 2015: Registration And Abstract Submission Now Open

25.03.2015 | Event News

University presidents from all over the world meet in Hamburg

19.03.2015 | Event News

10. CeBiTec Symposium zum Big Data-Problem

17.03.2015 | Event News

 
Latest News

Two Most Destructive Termite Species Forming Superswarms in South Florida

27.03.2015 | Agricultural and Forestry Science

ORNL-Led Team Demonstrates Desalination with Nanoporous Graphene Membrane

27.03.2015 | Materials Sciences

Coorong Fish Hedge Their Bets for Survival

27.03.2015 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>