Iron oxide nanoparticles are described for usage in therapeutic hyperthermia as well as for magnetic particle imaging and spectroscopy (MPI, MPS). Application of those particles in hyperthermia therapy (injection into tumor cells and exposure to an alternating magnetic field to damage tumor cells) is well known whereas MPI is a quite new tomographic imaging technique based on the non-linear magnetization behavior of superparamagnetic iron oxide nanoparticles (SPIOs). So far it is clear that MPI will have potential for many different diagnostic applications but it is still lacking appropriate SPIO tracers to achieve and guarantee the best possible image quality.<br><br> <strong>Technology</strong><br> The newly synthesized SPIO tracer for MPI according to this invention are assumed to have properties that guarantee a very well image quality and moreover enable them to be used in various biological systems and therewith in preclinical and clinical development. The SPIOs are provided as magnetic particle dispersion comprising single- or multi-core nanoparticles of iron oxides like magnetite and/or maghemite. For in vivo applications and stabilization the particles are coated with a biocompatible shell, preferably a polymer. In first experiments the dispersions showed an improved nonlinear magnetization behavior and a distinctive overtone structure that are clearly superior to SPIOs known in the state of the art so far. Moreover these SPIOs show improved heating properties when subjected to an alternating magnetic field. The proposed SPIO dispersions are suitable for applications in MPI, MRS, MRI, hyperthermia therapy, cell tracking and diagnosis of tumors, cardiovascular-, bone marrow-, lymph node- or liver diseases. <br> <br>
firstname.lastname@example.org | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.
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The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
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21.04.2017 | Physics and Astronomy