Iron oxide nanoparticles are described for usage in therapeutic hyperthermia as well as for magnetic particle imaging and spectroscopy (MPI, MPS). Application of those particles in hyperthermia therapy (injection into tumor cells and exposure to an alternating magnetic field to damage tumor cells) is well known whereas MPI is a quite new tomographic imaging technique based on the non-linear magnetization behavior of superparamagnetic iron oxide nanoparticles (SPIOs). So far it is clear that MPI will have potential for many different diagnostic applications but it is still lacking appropriate SPIO tracers to achieve and guarantee the best possible image quality.<br><br> <strong>Technology</strong><br> The newly synthesized SPIO tracer for MPI according to this invention are assumed to have properties that guarantee a very well image quality and moreover enable them to be used in various biological systems and therewith in preclinical and clinical development. The SPIOs are provided as magnetic particle dispersion comprising single- or multi-core nanoparticles of iron oxides like magnetite and/or maghemite. For in vivo applications and stabilization the particles are coated with a biocompatible shell, preferably a polymer. In first experiments the dispersions showed an improved nonlinear magnetization behavior and a distinctive overtone structure that are clearly superior to SPIOs known in the state of the art so far. Moreover these SPIOs show improved heating properties when subjected to an alternating magnetic field. The proposed SPIO dispersions are suitable for applications in MPI, MRS, MRI, hyperthermia therapy, cell tracking and diagnosis of tumors, cardiovascular-, bone marrow-, lymph node- or liver diseases. <br> <br>
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Bioabbaubare Nano- und Mesopolymerpartikel zum Schutz des pulmonalen Surfactants der Lunge
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Mutation Detection in ctDNA or CTC - Highly sensitive, fast and cost-effective detection of gene modifications and mutations in ctDNA or CTC
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Physicists of the Laboratory for Attosecond Physics at the Max Planck Institute of Quantum Optics and the Ludwig-Maximilians-Universität Munich in collaboration with scientists from the Friedrich-Alexander-Universität Erlangen-Nürnberg have observed a light-matter phenomenon in nano-optics, which lasts only attoseconds.
The interaction between light and matter is of key importance in nature, the most prominent example being photosynthesis. Light-matter interactions have also...
A biological and energy-efficient process, developed and patented by the University of Innsbruck, converts nitrogen compounds in wastewater treatment facilities into harmless atmospheric nitrogen gas. This innovative technology is now being refined and marketed jointly with the United States’ DC Water and Sewer Authority (DC Water). The largest DEMON®-system in a wastewater treatment plant is currently being built in Washington, DC.
The DEMON®-system was developed and patented by the University of Innsbruck 11 years ago. Today this successful technology has been implemented in about 70...
Permanent magnets are very important for technologies of the future like electromobility and renewable energy, and rare earth elements (REE) are necessary for their manufacture. The Fraunhofer Institute for Mechanics of Materials IWM in Freiburg, Germany, has now succeeded in identifying promising approaches and materials for new permanent magnets through use of an in-house simulation process based on high-throughput screening (HTS). The team was able to improve magnetic properties this way and at the same time replaced REE with elements that are less expensive and readily available. The results were published in the online technical journal “Scientific Reports”.
The starting point for IWM researchers Wolfgang Körner, Georg Krugel, and Christian Elsässer was a neodymium-iron-nitrogen compound based on a type of...
In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.
In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...
Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices
Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.
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