Small Molecule XIAP Inhibitor
Apoptosis is a highly conserved process regulating the balance between cell death and proliferation for the maintenance of tissue homeostasis. Inhibitor of apoptosis proteins (IAPs) are a group of antiapoptotic proteins that
inhibit caspases, central players in the apoptotic cascade. <p> XIAP, the most potent and well characterized member of the IAP family is an inhibitor of caspase-3, -7 and -9. Through virtual screening of commercially available databases several compounds were identified as novel XIAP inhibitors. These compounds, which showed no cytotoxicity on their own, were tested in a human leukaemia cell line stably overexpressing XIAP for their ability to overcome the cells’ chemoresistance. <p>In order to develop the full therapeutic potential of our XIAP inhibitors, we currently work on the underlying apoptosis signalling mechanisms, NMR binding studies, and towards an in vivo proof of principle.
Further Information: PDF
Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0
Contact
Peer Biskup
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Superradiant atoms could push the boundaries of how precisely time can be measured
Superradiant atoms can help us measure time more precisely than ever. In a new study, researchers from the University of Copenhagen present a new method for measuring the time interval,…
Ion thermoelectric conversion devices for near room temperature
The electrode sheet of the thermoelectric device consists of ionic hydrogel, which is sandwiched between the electrodes to form, and the Prussian blue on the electrode undergoes a redox reaction…
Zap Energy achieves 37-million-degree temperatures in a compact device
New publication reports record electron temperatures for a small-scale, sheared-flow-stabilized Z-pinch fusion device. In the nine decades since humans first produced fusion reactions, only a few fusion technologies have demonstrated…
