Chinese Hamster ovary (CHO) cells are commonly used as a mammalian expression system for the production of recombinant proteins. They are one of the few cell types that can be grown at high cell density as the cells are resistant to metabolic stress. However, given the considerable production costs it is of major importance to maximize the recombinant protein yield. The present invention allows for significantly increasing the recombinant protein expression level in CHO cells using a standard promoter. This is achieved by silencing the Galectin-1 gene through RNAi. The lentiviral Galectin-1-knockdown (>90%) increases the expression level of the protein of interest more than 1,5-fold. No further amendments are required.
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