A receptor-dead mutein of bone morphogenetic protein 2 (BMP-2)
A new receptor-dead BMP-2 mutein L51P has been created that has no detectable BMP activity. Surprisingly, the BMP-2 L51P mutein exhibits an unaltered binding affinity for BMP modulator proteins of the Noggin, Chordin and DAN families. In cell culture experiments the mutein has been demonstrated to efficiently neutralize Noggin activity.
Further Information: PDF
Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V.
Phone: +49 (0)89/1205-6000
Contact
Dr. Wolfgang Knappe
Media Contact
All latest news from the category: Technology Offerings
Newest articles
How 3D printers can give robots a soft touch
Soft skin coverings and touch sensors have emerged as a promising feature for robots that are both safer and more intuitive for human interaction, but they are expensive and difficult…
Oxygen vacancies mediated ultrathin Bi4O5Br2 nanosheets
… as efficient piezocatalyst for synthesis of H2O2 from pure water. As an important chemical raw material, hydrogen peroxide (H2O2) is widely applied in various aspects of industry and life….
Atom-by-atom: Imaging structural transformations in 2D materials
Silicon-based electronics are approaching their physical limitations and new materials are needed to keep up with current technological demands. Two-dimensional (2D) materials have a rich array of properties, including superconductivity…
