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High-resolution quantitative online measurement of cell signaling dynamics

01.09.2008
FRET basierte Biosensoren sind ein wichtiges Werkzeug, um die molekularen Dynamik der Makromoleküle zu verfolgen und Stoffwechselprodukte sowie Ionen in der lebenden Zelle zu bestimmen. Sie finden vermehrt Anwendung im Target- und Drug-Screening. Mangelhaft sind bis heute die niedrige zeitliche und räumliche Auflösung und die fehlerbehafteten quantitativen Resultate, die auf die Änderungen in den umgebenden Bedingungen eines lebenden Systems zurückzuführen sind. Hier stellen wir eine Lösung diese Problems vor, die Zugang zu verlässlichen quantitativen Resultaten während der Messung in lebenden Zellen mit einer ausgezeichneten räumlichen und zeitlichen Auflösung gibt. Dabei sind aus Sicht der Laborausrüstung nur günstige Standardgeräte erforderlich. Die Technik kann an YFP-basierten Biosensoren leicht angewendet und für die Grundlagenforschung sowie Hochdurchsatz-Screening von targets oder drugs in vitro und in vivo verwendet werden.



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