Athero-Blocker – New peptides for the prevention and treatment of atherosclerosis
Scientists at the RWTH Aachen have identified new
peptides which can be used for the prevention of atherosclerosis or in the treatment of related cardiovascular diseases. It is known that adherent activated platelets secrete chemoattractants, such as the chemokines PF4 and RANTES, which are responsible for monocyterecruitment. Receptor-blocking experiments and studies with knock-out mice indicated that RANTES signals contribute to intimal hyperplasia and macrophage infiltration in models of restenosis. Moreover, it plays an important role in the initiation and maintenance of atherosclerosis. Athero-Blocker is specifically targeting the interaction between the chemokines RANTES and PF4. It can thereby abrogate the proatherogenic enhancement of monocyte recruitment caused by this interaction. A good efficacy of Athero-Blocker has been demonstrated in in vitro experiments, in cell based test systems and in mouse models in vivo.
Further Information: PDF
PROvendis GmbH
Phone: +49 (0)208/94105 0
Contact
Dipl.-Ing. Alfred Schillert
Media Contact
All latest news from the category: Technology Offerings
Newest articles
“Nanostitches” enable lighter and tougher composite materials
In research that may lead to next-generation airplanes and spacecraft, MIT engineers used carbon nanotubes to prevent cracking in multilayered composites. To save on fuel and reduce aircraft emissions, engineers…
Trash to treasure
Researchers turn metal waste into catalyst for hydrogen. Scientists have found a way to transform metal waste into a highly efficient catalyst to make hydrogen from water, a discovery that…
Real-time detection of infectious disease viruses
… by searching for molecular fingerprinting. A research team consisting of Professor Kyoung-Duck Park and Taeyoung Moon and Huitae Joo, PhD candidates, from the Department of Physics at Pohang University…