Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Specific inhibitors of 11beta-HSD1

The crucial point in glucocorticoid related diseases, including type 2 diabetes, metabolic syndrome, obesity, hyperglycaemia, arteriosclerosis, dementia, depression and osteoporosis is the ratio of cortisone/cortisol, too much cortisol results in described diseases.

11beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1) plays an important role in converting cortisone to cortisol, while 11beta-hydroxysteroid dehydrogenase type 2 (11b-HSD2) only acts as a deydrogenase by inactivating cortisol to cortisone. Due to their non-specificity compounds like 18beta-Glycyrrhetinic acid cause adverse effects, among other things hypertension. Therefore, a selective inhibitor of 11b-HSD1 has considerable potential as a drug directed against glucocorticoid related metabolic disorders. The invention results in new compounds with an oleanan or ursan scaffold which specific inhibit 11b-HSD1 and not 11b-HSD2. The structural determinants for specific inhibition are figured out and new approaches to synthesize specific 11b-HSD1 inhibitors with oleanan or ursan scaffold are shown. Selective 11b-HSD1 inhibitors with an oleanan or ursan scaffold should have the advantage of low toxicity, the possibility of modification of the scaffold to influence pharmacokinetic and –dynamic properties, as well as sufficient sources in nature.

Further Information: PDF

Patent- und Verwertungsagentur für die Wissenschaftlichen Einrichtungen in Schleswig-Holstein GmbH (PVA SH)
Phone: +49 (0)431/8009937

Dr. Alexandra Baumgartner | TechnologieAllianz e.V.
Further information:

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Tiny implants for cells are functional in vivo

For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.

In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

Latest News

A new kind of quantum bits in two dimensions

19.03.2018 | Physics and Astronomy

Scientists have a new way to gauge the growth of nanowires

19.03.2018 | Materials Sciences

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Science & Research
Overview of more VideoLinks >>>