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Synthetic K receptor agonist for pain therapy - Novel class of k selective opioids for peripheral pain treatment

22.02.2008
Natural and synthetic opioids are effective and widely

used drugs for the treatment of acute, post-operative or malignant pain. These drugs interact predominantly with μ-opioid receptors in the central nervous system. While being strong analgesics, these drugs also cause severe side effects due to their interaction with μ-opioid receptors

in the brain. This limits the use of currently available opioids for palliative care. Not many drugs are available for the treatment of severe peripheral, chronic, neuropathic or non-malignant pain. However, k-opioid receptor agonists with high k receptor affinity and selectivity, which cannot pass the blood brain barrier, are suitable for this purpose. At the University of Münster, a new class of compounds with high k receptor affinity and selectivity as well as strong analgesic effects has been developed.

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