Purin-Ago: Non-nucleotide agonists of the P2Y11-receptor with immunosuppressant effect
Purinergic receptors have been in the focus of drug discovery for many years. This invention provides nonnucleotide
agonists of the P2Y11-receptor. The agonists ensure high specificity among P2-receptors which is a key to tolerability of compounds meant for applications in longterm treatment settings. Activation of the P2Y11-receptor leads to a variety of effects in the modulation of immune system activity. For example release of immune modulatory thrombospondin-1 is induced, while lipopolysaccharide (LPS)-stimulated release of the pro-inflammatory cytokine interleukin-12 (IL- 12) is inhibited by activation of the P2Y11-receptor.
Further Information: PDF
PROvendis GmbH
Phone: +49 (0)208/94105 0
Contact
Dipl.-Ing. Alfred Schillert
Media Contact
All latest news from the category: Technology Offerings
Newest articles
“Nanostitches” enable lighter and tougher composite materials
In research that may lead to next-generation airplanes and spacecraft, MIT engineers used carbon nanotubes to prevent cracking in multilayered composites. To save on fuel and reduce aircraft emissions, engineers…
Trash to treasure
Researchers turn metal waste into catalyst for hydrogen. Scientists have found a way to transform metal waste into a highly efficient catalyst to make hydrogen from water, a discovery that…
Real-time detection of infectious disease viruses
… by searching for molecular fingerprinting. A research team consisting of Professor Kyoung-Duck Park and Taeyoung Moon and Huitae Joo, PhD candidates, from the Department of Physics at Pohang University…