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Improving Bioavailability

21.01.2008
The amidine group is an essential component of many pharmacologically active agents. However, in general pharmaceutical compositions with one or more amidine functions are almost inactive if given orally and must therefore be administered by injection. The present invention consists in a modification of at least one of the amidine functions of a pharmacological agent, resulting in its effective resorption via oral administration, followed by its conversion back into the original active form, the amidine, by the body’s own enzymes (prodrug principle).

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