There are various methods for deoxygenation of amides, wherein metal hydrides as reducing agents are generally used. This exothermic reaction is accompanied by the formation of hydrogen and therefore requires extensive safety precautions. In addition, appearing side products like oxides and hydroxides have to be separated which is time-consuming and costly.
Beyond that, there are procedural devices for the electrochemical production of amines which however merely allow the synthesis of primary amines.
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