Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Preservation solution for organ transplantation

Ischemia-reperfusion injury contributes to allograft dysfunction and loss. Preservation solutions in organ transplantation are used for the preservation of allografts during transportation from the donor to the recipient in order to preserve organ function. Due to improved protective effects the present preservation solution is to confer prolonged survival and significantly enhanced function of the allograft. This may not only lead to improved quality of life, but also to a reduction in the number of patients awaiting transplantation. Preclinical studies led to the identification of the vasoprotecitve effects of statins associated with improved organ function following ischemiareperfusion. Statins are inhibitors of hydroxymethylglutaryl-coenzymA-reductase-

Inhibitoren that are approved for lowering serum cholesterol levels. Statins exhibit several ideal properties for their use in organ transplantation, i.e. reduction of oxidative stress, improvement of endothelial function. Moreover, statins increase the bioavailability of NO that causes vasodilatation and thus improves blood flow. Two compounds of the statin family were identified to be appropriate for the use in preservation solutions, pravastatin und simvastatin. Both compounds are not subject to patent protection. Therefore, production is easy and cost effective. Moreover, statins have been introduced to the market many years ago and there is a large body of experience in other indications.

Further Information: PDF

Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0

Peer Biskup | TechnologieAllianz e.V.
Further information:

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Innovative technique for shaping light could solve bandwidth crunch

20.10.2016 | Physics and Astronomy

Finding the lightest superdeformed triaxial atomic nucleus

20.10.2016 | Physics and Astronomy

NASA's MAVEN mission observes ups and downs of water escape from Mars

20.10.2016 | Physics and Astronomy

More VideoLinks >>>