A novel drug polymer conjugate consisting of a dendritic polyglycerine (PG) core of 3-5 or more glycerol units and a polyethylene glycol shell has been developed. The pharmaceutically or diagnostically compound is covalently bound to a glycerol unit through a cleavable linker (and optionally an addi-tional spacer). Dependently on the used linker, the compound can be cleaved physically or chemically e.g. by light, heat, or by hydrolysis, pH-dependent cleavage or cleavage by enzymes. As there are multiple glycerol units, more than one binding site exists, so that more than one active compound can be coupled to the same carrier molecule. Moreover, one carrier molecule also enables the loading of different pharmaceutically compounds (combinational therapy). These carriers are suitable for conjugation of various drug agents or diagnostically compounds such as e.g. cytostatic agents, cytokines, immune-suppressants, virostatics and radioactive agents, light-emitting or light absorbing substance, which allows the application in therapies of various diseases. The polymer drug conjugate may be suitable for the patient in an injectable form, as a tablet or a capsule, or as composition for inhalation. </p> <p><strong>Benefits</strong>
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Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
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