Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Polygenic Mouse Model for Juvenile Obesity Research


We offer two well-characterized polygenic mouse models that allow the test of drugs for weight loss and the targeted search for genetic factors influenc-ing fat deposition: The Berlin Fat Mouse (BFM) outbred population and the Berlin Fat Mouse Inbred 860 (BFMI860) strain. BFM has been selected for low protein content and for high fatness and low body mass from a base population of animals bought in several Berlin pet shops. BFMI860 is an inbred derivate of BFM that has been generated by repeated mating of most obese BFM full-sibs after 58 generations of selection. BFM and BFMI860 develop extreme body weight with high body fat mass, but only marginal increased body lean mass. The phenotype is visible already at a very early age. Highest weight gain occurs between 6 and 10 weeks. At standard diet, the adult animals of the BFMI860 strain had a body fat percentage of 22 to 30% in males and 28 to 37% in females compared to 6% in wildtype mice. The animals respond to high fat diet with further increase of adiposity. BFMI860 mice show several features of the metabolic syndrome. <br><br> Consistent with the high genetic variability, BFM animals have a higher varia-bility in the fat percentage and related phenotypes than BFMI860. </p> <p><strong>Benefits</strong><br>

<ul> <li>BFM and BFMI860 dispose of more body weight, body fat mass and body lean mass (protein mass) than wt (Wagener et al. 2006)</li> <li>BFMI exhibit general increase in body fat mass but only marginal increase in body lean mass in contrast to other growth-selected mouse lines </li> </ul> <p><strong>Origin</strong><br> The development was made by the Humboldt-Universität zu Berlin.

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Dr. Dirk Dantz | TechnologieAllianz e.V.
Further information:

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>