Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Polygenic Mouse Model for Juvenile Obesity Research

07.09.2012
<strong>Technology</strong><br>

We offer two well-characterized polygenic mouse models that allow the test of drugs for weight loss and the targeted search for genetic factors influenc-ing fat deposition: The Berlin Fat Mouse (BFM) outbred population and the Berlin Fat Mouse Inbred 860 (BFMI860) strain. BFM has been selected for low protein content and for high fatness and low body mass from a base population of animals bought in several Berlin pet shops. BFMI860 is an inbred derivate of BFM that has been generated by repeated mating of most obese BFM full-sibs after 58 generations of selection. BFM and BFMI860 develop extreme body weight with high body fat mass, but only marginal increased body lean mass. The phenotype is visible already at a very early age. Highest weight gain occurs between 6 and 10 weeks. At standard diet, the adult animals of the BFMI860 strain had a body fat percentage of 22 to 30% in males and 28 to 37% in females compared to 6% in wildtype mice. The animals respond to high fat diet with further increase of adiposity. BFMI860 mice show several features of the metabolic syndrome. <br><br> Consistent with the high genetic variability, BFM animals have a higher varia-bility in the fat percentage and related phenotypes than BFMI860. </p> <p><strong>Benefits</strong><br>

<ul> <li>BFM and BFMI860 dispose of more body weight, body fat mass and body lean mass (protein mass) than wt (Wagener et al. 2006)</li> <li>BFMI exhibit general increase in body fat mass but only marginal increase in body lean mass in contrast to other growth-selected mouse lines </li> </ul> <p><strong>Origin</strong><br> The development was made by the Humboldt-Universität zu Berlin.

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Contact
Dr. Dirk Dantz

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2745&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>