Novel peptide inhibitors for the treatment of malignant melanoma
Malignant melanoma is characterized by aggressive local growth and early formation of metastasis. The Melanoma Inhibitory Activity (MIA) protein is known to promote invasion of melanoma cells into healthy tissue and triggers formation of metastases. After determining the functional state of MIA, the inventors of the University of Regensburg (Germany) have identi ed several peptides which inhibit MIA protein functional activity and strongly reduce the formation of metastases in vivo. These inhibitors may offer a novel treatment strategy in preventing or reducing of formation of metastases in malignant melanoma.
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