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Use of penta halogen cyanocinnamic acid derivates as matrices for MALDI mass spectrometry

01.07.2011
The MALDI-MS (matrix-assisted laser desorption/ionization mass spectrometry) is an established standard method in bioanalytics, which is used mainly in the investigation of large molecules and polymers.

The present invention relates to newly developed MALDI-MS matrices which are based on 5-fold halogenated cyanocinnamic acid derivates, allowing a very sensitive detection of biomolecules and in particular of proteins and peptides.

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