Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nucleoside analogs in combination with Nodal, SHH or mTOR inhibitors for eliminating epithelial cancer stem cells (CSC)

22.07.2010
Epithelial cancers are among the most

frequent causes of death. Especially pancreatic carcinomas are characterized by early metastatic spread and a pronounced resistance to chemotherapy and radiation. Despite extensive

research activities in the field of tumor biology, there has hardly been any substantial progress within the past decades regarding therapeutic success. The introduction of the chemotherapeutic agent gemcitabine improved clinical response by reducing pain and loss of weight. As the median 5-year survival rate (1-4%) and the median survival time (5 months) are very low, the prognosis of patients with pancreatic cancer has remained poor. During the last years, it has been shown that stem cells play a decisive role in the development and progression of cancer and that distinct populations of cells with stem cell properties may be essential for the development and perpetuation of various human cancers, including pancreatic cancer, colon cancer, lung cancer, breast cancer and brain tumor. Unfortunately, conventional therapy using chemotherapy or radiation seems to have little to no effect on cancer stem cells (CSC). If a tumor is depleted of CSC, it will lose its exclusive source for growth promotion and metastasis and will eventually degrade due to the limited self-renewal capacity and life span of more differentiated tumor cells. The current inventions are based on combination therapies of nucleoside analogs with inhibitors of either the Nodal/Activin pathway or the mTOR / hedgehog pathway and show a remarkable capacity to eliminate cancer stem cells and to subsequently inhibit pancreatic cancer.

Further Information: PDF

Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0

Contact
Peer Biskup

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=1498&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>