NMDA Antagonists – New selective compounds to the NR2B subunit with high affinity
he NMDA receptor, an ion channel consisting of several protein subunits, is involved in the pathophysiology of chronic neurodegenerative diseases, depression, pain and alcoholism. Different subtypes of NMDA receptors can be categorized based on their subunit composition. The NR2B subunit expression is mostly localized in forebrain regions including cortex, hippocampus and striatum.
NR2B-selective antagonists have received considerable attention in recent years as they have shown efficacy in neuroprotection, anti-hyperalgesic and anti-Parkinson animal models. NR2B antagonists bind preferentially to the activated form of the NMDA receptor containing the NR2B subunit and allosterically modulate channel activity by inhibiting channel opening probability. They show advantages over non-selective NMDA receptor antagonists due to greater separation between efficacy and side effects.
Further Information: PDF
PROvendis GmbH
Phone: +49 (0)208/94105 10
Contact
Dipl.-Ing. Alfred Schillert
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Superradiant atoms could push the boundaries of how precisely time can be measured
Superradiant atoms can help us measure time more precisely than ever. In a new study, researchers from the University of Copenhagen present a new method for measuring the time interval,…
Ion thermoelectric conversion devices for near room temperature
The electrode sheet of the thermoelectric device consists of ionic hydrogel, which is sandwiched between the electrodes to form, and the Prussian blue on the electrode undergoes a redox reaction…
Zap Energy achieves 37-million-degree temperatures in a compact device
New publication reports record electron temperatures for a small-scale, sheared-flow-stabilized Z-pinch fusion device. In the nine decades since humans first produced fusion reactions, only a few fusion technologies have demonstrated…