Mutations of Histone Proteins Associated With Proliferative Disorders
The identification of two H3.3 mutations allow the categorization of pediatric brain cancer patients into patients with grade IV pediatric GBM (P<0.0001) and grade III pediatric anaplastic astrocytoma (p<0.0078) and diffuse intrinsic diffuse intrinsic pontine gliomas. Occurrence of these mutations is linked to lower survival rate and help physicians in the clinical decision making process.
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