Cancer is still the main cause of death despite the development of many treatment strategies, including extensive radiation and chemotherapy. Clinical and research results from animal test have shown that, besides viruses, bacteria and parasites, the T-cell system can also recognize malignant abnormal cells and is able to destroy those. Especially CD8+ T-cells (cytotoxic T lymphocytes, CTLs) can cause responses of tumor repulsion by the recognition of antigens that are presented on the cell surface by Major Histocompatibility Complex Class I molecules (MHC, in humans HLA Class I). This invention offers the application of HLAindependent recognition of tumorassociated antigens for diagnosis, therapy and prevention of melanoma and other tumor types. Two antigens are presented that can be recognized by CTLs independently of HLA and whose application in cancer immune therapy will unlock new therapy alternatives. [Reference HMZ077]
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IMG Innovations-Management GmbH
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Dr. Klaus Kobek
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