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MHC-independent tumor antigens for cancer immunotherapy


Cancer is still the main cause of death despite the development of many treatment strategies, including extensive radiation and chemotherapy. Clinical and research results from animal test have shown that, besides viruses, bacteria and parasites, the T-cell system can also recognize malignant abnormal cells and is able to destroy those. Especially CD8+ T-cells (cytotoxic T lymphocytes, CTLs) can cause responses of tumor repulsion by the recognition of antigens that are presented on the cell surface by Major Histocompatibility Complex Class I molecules (MHC, in humans HLA Class I). This invention offers the application of HLAindependent recognition of tumorassociated antigens for diagnosis, therapy and prevention of melanoma and other tumor types. Two antigens are presented that can be recognized by CTLs independently of HLA and whose application in cancer immune therapy will unlock new therapy alternatives. [Reference HMZ077]

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IMG Innovations-Management GmbH
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Dr. Klaus Kobek

As Germany's association of technology- and patenttransfer agencies TechnologieAllianz e.V. is offering businesses access to the entire range of innovative research results of almost all German universities and numerous non-university research institutions. More than 2000 technology offers of 14 branches are beeing made accessable to businesses in order to assure your advance on the market. At a free, fast and non-bureaucratic access to all further offers of the German research landscape is offered to our members aiming to sucessfully transfer technologies. | TechnologieAllianz e.V.
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