We here describe a new method for producing a highly diverse antibody library, where pro-teins/antibodies can be selected for specific ap-plications. A large and, compared from cell to cell, highly uniform number of antibodies is covalently attached to the surface of a eukaryotic cell. Using this technology, specific antibodies can be se-lected together with the presenting cell out of a high number of cells in a comparatively easy way. The technology can also be used humanizing a hybridoma cell line by enabling the homologous recombination of the constant domains of human immunoglobulins with the respective gene.
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DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
Phone: +49-6221-42 2955
Dr. Ruth Herzog
firstname.lastname@example.org | TechnologieAllianz e.V.
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