MCR Dendrimers

Dendrimers are spherical, highly branched polymers used in the fields of drug delivery and drug targeting, DNA/RNA delivery, imaging, protein labelling, protein crosslinking and protein separation, coagulation inhibition, and surface, cell and tissue recognition. They are also used as macroamphiphiles and catalyst supports. All previously existing dendrimers require special, branched and partially protected or polyreactive building blocks for their synthesis. A disadvantage is the limited range of dendrimers with varying structures that can be produced, and the concentration to few dendron forming functional groups.
The new technology offers the possibility of synthesising dendrimers with almost any combination of branch lengths, degree of branching, internal and terminal groups. This is achieved by means of multiple iterative multicomponent reactions, e.g. with acidic, alkaline, hydrophilic, lipophilic, sugar and other functional groups.

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