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Magnetic macromolecules of defined adjustable size and properties

27.03.2012
Magnetic particles and molecules have the advantage that their movement and localisation can be controlled by a magnetic field. In an application called Magnetofection, magnetic nanoparticles are, e.g., used deliver cargo such as DNA to cells to improve transfection. The invention describes star-shaped magnetic nanoparticles. These structures are readily taken up by cells including, suspension, primary and blood cells (human T-lymphocytes). No magnetic field is required for cellular uptake. Once inside cells, however, the particles (alone or cargo-loaded) stay magnetically active.

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