Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

KERatin - 3D artificial skin models for therapy strategies of keratinisation disorders

02.11.2009
The present invention describes a 3D model mimicking normal skin. The model shows the following advantages:

- a collagen-fibroblast matrix and a fully stratified and cornified epidermal layer of primary human keratinocytes - epidermal basal layer and terminal differentiation can be seen - barrier function is present (normal skin) or reduced (disease model) - able to mimic single gene caused keratinisation disorders, e.g. congenital ichthyosis

Challenge Since European and national regulations restrict the use of animals for the production and development of cosmetic products, adequate skin models are required. Pharmacological and pharmaceutical studies are presently done in 2D cell cultures, rodents and finally in humans. All these test systems either lack the genetic defect and disease phenotype that the drug is intended to cure or have to be developed tediously. Pharmacological and medical outcomes are thereto only predictable, as drug metabolism, drug transfer, e. g. through the epidermis, drug effect (in skin with missing gene products) cannot be foreseen.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 10

Contact
Dipl.-Ing. Alfred Schillert

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=1729&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Novel chip-based gene expression tool analyzes RNA quickly and accurately

18.01.2018 | Medical Engineering

Scientists on the road to discovering impact of urban road dust

18.01.2018 | Ecology, The Environment and Conservation

Gran Chaco: Biodiversity at High Risk

17.01.2018 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>