With their broad field of application in basic research, diagnostics and therapy, antibodies represent one of the most important groups of proteins in biotechnology. However, due to their complex folding and assembly, industrial production of antibodies is costly. Consequently, improving antibody properties is of high commercial interest. The present technology here improves antibody´s biophysical properties by introducing two intra-molecular modifications in the antibody structure. This results in an significantlyenhancedstabilityandsecretion.
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