Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Histone Deacetylase 10-inhibitor Co-Treatment in Cancer

23.11.2012
Histone deacetylase inhibitors (HDACi) are promising anticancer agents and are currently being evaluated in clinical trials. However, due to their unselective action, pan-HDACi exhibit dose-limiting side-effects restricting their full potential in anti-cancer therapy. Therefore, characterization of the molecular function of single HDAC isozymes is of major importance for a targeted therapy with less side-effects. We show that HDAC10 overexpression mediated cell survival and targeting of HDAC10 sensitized tumor cells for cytotoxic drug treatment and it correlates with progression or recurrence of neuroblastoma in vivo. These results demonstrate for the first time that HDAC10 induces an alternative lysosomal-mediated tumor cell death pathway, re-sensitizes cells for cytotoxic drugs and may thus be a novel strategy for neuroblastoma therapy.

Further Information: PDF

Deutsches Krebsforschungszentrum DKFZ
Phone: +49-6221-42 2955

Contact
Dr. Ruth Herzog

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2986&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht EPAP - Corrosion prevention in NMC-cathodes for lithium-ion batteries
25.02.2015 | TechnologieAllianz e.V.

nachricht Particles for optional perfusion diagnosis
24.02.2015 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

European Geosciences Union meeting: programme online, provisional press conference topics

26.02.2015 | Event News

Round Table on Solar Energy Research

18.02.2015 | Event News

40th FEBS Congress 2015 – The Biochemical Basis of Life

09.02.2015 | Event News

 
Latest News

Researchers create self-reconstructive metal wire utilizing electric field trapping of gold nanoparticles

27.02.2015 | Power and Electrical Engineering

Climate-Change Clues From the Turtles of Tropical Wyoming

27.02.2015 | Ecology, The Environment and Conservation

Pockets of Calm Protect Molecules Around a Supermassive Black Hole

27.02.2015 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>