Autoantibodies (autoAB) against the insulin receptor (IR) are known to cause a rare form of diabetes, i.e. insulin resistance type B. AutoAB against the structurally and functionally related receptor for insulin-like growth factor-1 (IGF1R) have only recently been described and are implicated in autoimmune diseases. However, the prevalence and clinical importance of these autoAB are not yet fully understood as respective sensitive and non-radioactive test systems for routine use were missing. A reliable assay system for the detection and quantification of these autoAB should be met with highest interest by basic researchers and clinicians alike, especially in the fields of diabetes, growth and cancer research, given the central importance of the insulin and IGF1 hormone axes for controlling growth, glucose metabolism and cell proliferation in humans.<br><br> <strong>Technology</strong><br> Two novel non-radioactive and highly sensitive immunoassays for detection and quantification of autoAB against the IR and IGF1R have been developed. For reasons of sensitivity, specificity and automation, the bridge technology has been chosen as most suitable assay format (see scheme). Using these novel in vitro diagnostica, autoAB against the IR and the IGF1R are detected with an astonishing 10% prevalence in the adult population. Notably, a high proportion of cross-reacting autoAB are found, reacting with similar strength to both the IR and IGF1R. The clinical and diagnostic importance of these results remains to be established in ongoing studies.<br><br>
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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