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Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering

16.10.2012
DKFZ together with Technical University of Denmark (DTU) developed an analogue of Griseofulvin as a compound for cancer treatment, which selectively targets cancer cells only.

Griseofulvin is a natural antibiotic produced by Penicillium griseofulvum as well as other microfungi and is still commonly used in humans for the treatment of dermatomycoses of skin, hair, and nails caused by Microsporum, Trichophyton, and Epidermophyton. Further hit to lead development of the natural compound was achieved by medicinal chemistry with corresponding biological activity tests.

Advantages - drug which selectively targets cancer cells only with little effect on normal tissues - possible treatment of several cancer types - analogue of natural compound (griseofulvin, orally available, almost no side effects in humans), thoroughly studied in biological tests

Further Information: PDF

Deutsches Krebsforschungszentrum DKFZ
Phone: +49-6221-42 2955

Contact
Dr. Ruth Herzog

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2938&lang=en
http://www.technologieallianz.de

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